Caffeine + Paracetamol

Indications

Caffeine + Paracetamol is used for: Mild to moderate pain, fever, headache, toothache, period pains, migraine, sore throat, backache

Adult Dose

Adult: 1-2 tablets every 4-6 hours. Maximum dose: 8 tablets daily.

Child Dose

Renal Dose

Administration

Contra Indications

Hypersensitivity Hepatitis or severe hepatic/renal impairment

Precautions

Discontinue use and ask a healthcare professional if any new symptoms occur, painful area is red or swollen, pain gets worse or lasts for more than 10 days, fever gets worse or lasts for more than 3 days Acetaminophen Risk for rare, but serious skin reactions that can be fatal; these reactions include Stevens-Johnson Syndrome (SJS), toxic epidermal necrolysis (TEN), and acute generalized exanthematous pustulosis (AGEP); symptoms may include skin redness, blisters and rash Hypersensitivity and anaphylactic reactions reported; discontinue immediately if symptoms of allergic or hypersensitivity reactions occur Acetaminophen is available in many dosage forms and products, check label carefully to avoid overdose Use caution in patients with hepatic impairment or active liver disease Risk of hepatotoxicity is higher in patients taking chronic high dose, or use of more than one acetaminophen-containing product Use caution in patients with severe renal impairment; consider dosage adjustments Consumption of 3 or more alcoholic drinks/day may increase risk of liver damage Use with caution in patients with G6PD deficiency Use caution in patients with chronic malnutrition Caffeine The recommended dose of this product contains about as much caffeine as a cup of coffee. Limit the use of caffeine-containing medications, foods, or beverages while taking this product because too much caffeine may cause nervousness, irritability, sleeplessness, and occasionally, rapid heartbeat

Pregnancy-Lactation

Pregnancy Acetaminophen Drug crosses placenta and can be detected in cord blood, newborn serum, and urine immediately after delivery Increased risk of teratogenic effects not reported following maternal use of drug during pregnancy Use of normal doses during pregnancy not associated with increased risk of miscarriage or stillbirth; however, increase in fetal death or spontaneous abortion may be seen with maternal overdose if treatment delayed Wheezing and asthma in early childhood associated with frequent maternal use of drug during pregnancy Caffeine Caffeine crosses placenta; serum concentration in fetus are similar to that of the mother; dietary exposure unlikely to cause congenital malformations; unknown whether it may increase risk of other adverse events, including abortion or growth retardation Current maternal consumption of high amounts of caffeine during pregnancy may lead to neonatal withdrawal at delivery; current guidelines recommend limiting caffeine intake from all sources to <200 mg/day during pregnancy Lactation Acetaminophen Drug is excreted in milk; in general, breastfeeding is generally acceptable if relative infant dose (RID) is <10%; avoid breastfeeding when RID>25% Caffeine Caffeine and metabolites are present in breast milk; moderate amounts of caffeine are considered acceptable with breastfeeding; ingestion of <300 mg/day recommended; use caution if breastfeeding premature infants, or infants small for gestational age, or consuming unusually high amounts of caffeine

Interactions

Contraindicated (7) fezolinetant isocarboxazid linezolid phenelzine procarbazine selegiline transdermal tranylcypromine

Adverse Effects

Side effects of Caffeine + Paracetamol : Acetaminophen Pruritic maculopapular rash Urticaria Laryngeal edema Angioedema Anaphylactoid reaction Thrombocytopenia Leukopenia Pancytopenia Neutropenia Thrombocytopenic purpura Agranulocytosis Hepatotoxicity May increase uric acid, chloride, glucose May decrease sodium, calcium, bicarbonate Caffeine Insomnia Restlessness Nervousness Tremor Tinnitus Irritability Nausea Vomiting Diarrhea Tachycardia Diuresis Palpitations (dose dependent)

Mechanism of Action

Acetaminophen: Acetaminophen: Inhibitis prostaglandin sythesis in CNS and may block peripheral pain impulse generation; acts on hypothalamus to antipyresis Caffeine: Vasoconstrictive properties may be helpful when treating vascular headaches