Paracetamol Extra Tablet
Caffeine + Paracetamol
65 mg + 500 mg
Pharmik Laboratories Ltd.
| Pack size | 100's, 200's Pack |
|---|---|
| Dispensing mode | |
| Source | |
| Agent | |
| Retail Price | 2.00 AED |
Indications
Paracetamol Extra Tablet is used for:
Mild to moderate pain, fever, headache, toothache, period pains, migraine, sore throat, backache
Adult Dose
Adult:
1-2 tablets every 4-6 hours.
Maximum dose: 8 tablets daily.
Child Dose
Renal Dose
Administration
Contra Indications
Hypersensitivity
Hepatitis or severe hepatic/renal impairment
Precautions
Discontinue use and ask a healthcare professional if any new symptoms occur, painful area is red or swollen, pain gets worse or lasts for more than 10 days, fever gets worse or lasts for more than 3 days
Acetaminophen
Risk for rare, but serious skin reactions that can be fatal; these reactions include Stevens-Johnson Syndrome (SJS), toxic epidermal necrolysis (TEN), and acute generalized exanthematous pustulosis (AGEP); symptoms may include skin redness, blisters and rash
Hypersensitivity and anaphylactic reactions reported; discontinue immediately if symptoms of allergic or hypersensitivity reactions occur
Acetaminophen is available in many dosage forms and products, check label carefully to avoid overdose
Use caution in patients with hepatic impairment or active liver disease
Risk of hepatotoxicity is higher in patients taking chronic high dose, or use of more than one acetaminophen-containing product
Use caution in patients with severe renal impairment; consider dosage adjustments
Consumption of 3 or more alcoholic drinks/day may increase risk of liver damage
Use with caution in patients with G6PD deficiency
Use caution in patients with chronic malnutrition
Caffeine
The recommended dose of this product contains about as much caffeine as a cup of coffee. Limit the use of caffeine-containing medications, foods, or beverages while taking this product because too much caffeine may cause nervousness, irritability, sleeplessness, and occasionally, rapid heartbeat
Pregnancy-Lactation
Pregnancy
Acetaminophen
Drug crosses placenta and can be detected in cord blood, newborn serum, and urine immediately after delivery
Increased risk of teratogenic effects not reported following maternal use of drug during pregnancy
Use of normal doses during pregnancy not associated with increased risk of miscarriage or stillbirth; however, increase in fetal death or spontaneous abortion may be seen with maternal overdose if treatment delayed
Wheezing and asthma in early childhood associated with frequent maternal use of drug during pregnancy
Caffeine
Caffeine crosses placenta; serum concentration in fetus are similar to that of the mother; dietary exposure unlikely to cause congenital malformations; unknown whether it may increase risk of other adverse events, including abortion or growth retardation
Current maternal consumption of high amounts of caffeine during pregnancy may lead to neonatal withdrawal at delivery; current guidelines recommend limiting caffeine intake from all sources to <200 mg/day during pregnancy
Lactation
Acetaminophen
Drug is excreted in milk; in general, breastfeeding is generally acceptable if relative infant dose (RID) is <10%; avoid breastfeeding when RID>25%
Caffeine
Caffeine and metabolites are present in breast milk; moderate amounts of caffeine are considered acceptable with breastfeeding; ingestion of <300 mg/day recommended; use caution if breastfeeding premature infants, or infants small for gestational age, or consuming unusually high amounts of caffeine
Interactions
Contraindicated (7)
fezolinetant
isocarboxazid
linezolid
phenelzine
procarbazine
selegiline transdermal
tranylcypromine
Adverse Effects
Side effects of Caffeine + Paracetamol :
Acetaminophen
Pruritic maculopapular rash
Urticaria
Laryngeal edema
Angioedema
Anaphylactoid reaction
Thrombocytopenia
Leukopenia
Pancytopenia
Neutropenia
Thrombocytopenic purpura
Agranulocytosis
Hepatotoxicity
May increase uric acid, chloride, glucose
May decrease sodium, calcium, bicarbonate
Caffeine
Insomnia
Restlessness
Nervousness
Tremor
Tinnitus
Irritability
Nausea
Vomiting
Diarrhea
Tachycardia
Diuresis
Palpitations (dose dependent)
Mechanism of Action
Acetaminophen: Acetaminophen: Inhibitis prostaglandin sythesis in CNS and may block peripheral pain impulse generation; acts on hypothalamus to antipyresis
Caffeine: Vasoconstrictive properties may be helpful when treating vascular headaches
Note
Paracetamol Extra 65 mg + 500 mg Tablet manufactured by Pharmik Laboratories Ltd.. Its generic name is Caffeine + Paracetamol. Paracetamol Extra is availble in Bangladesh.
Farmaco BD drug index information on Paracetamol Extra Tablet is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.