Bambuterol Hydrochloride
Indications
Bambuterol Hydrochloride is used for:
Chronic obstructive pulmonary disease (COPD), Asthma.
Adult Dose
Adult: PO 10-20 mg once daily at bedtime.
Child Dose
Children 2-5 years: The recommended normal dose 10 mg (10 ml syrup).
Children 6-12 years: The recommended normal dose 10 mg (10 ml syrup). The dose may be increased to 20 mg.
Renal Dose
Renal impairment:
CrCl (ml/min)
<50 Initial dose should be halved.
Administration
Contra Indications
Severe hepatic impairment; cirrhosis.
Precautions
DM, hyperthyroidism, myocardial insufficiency, arrhythmias, susceptibility to QT-interval prolongation. Pregnancy.
Pregnancy-Lactation
Although no teratogenic effects have been observed in animals after administration of bambuterol, caution is recommended during the first trimester of pregnancy.
It is not known whether bambuterol or intermediary metabolites pass over to breast milk, so caution is recommended if bambuterol is administered to patients who are breast feeding. Terbutalin passes over to breast milk but an influence on the child is unlikely with therapeutic doses.
Transient hypoglycemia has been reported in newborn pre-term infants after maternal ß2 agonist treatment.
Interactions
Risk of hypokalaemia increased by co-admin of corticosteroids, diuretics or xanthines. Prolong the action of drugs e.g. suxamethonium.
Adverse Effects
Side effects of Bambuterol Hydrochloride :
Fine tremor of skeletal muscle (e.g. hands), palpitations and muscle cramps; tachycardia, tenseness and peripheral vasodilation.
Mechanism of Action
Bambuterol HCl is a prodrug of terbutaline. It relaxes bronchial smooth muscle by selectively acting on ?2-receptors.