Dotiric Tablet
Dotinurad
0.5 mg
Everest Pharmaceuticals Ltd.
| Pack size | 30's pack |
|---|---|
| Dispensing mode | |
| Source | |
| Agent | |
| Retail Price | 6.00 AED |
Available as:
Indications
Dotiric Tablet is used for:
Gout, Hyperuricemia
Adult Dose
Oral
Tablet
Initially 0.5 mg tab once a day.
The dosage may gradually increase according to blood uric acid level as needed.
It may be increased to 1 mg at a time, once a day after 2 weeks, and then 2 mg at a time, once daily as a maintenance dose after 6 weeks.
The dosage may be adjusted according to the patient's condition.
However, it should not exceed 4 mg at a time, once a day.
Hepatic impairment
Dotinurad can be administered to patients with hepatic impairment without dose adjustment.
Child Dose
Renal Dose
No dose adjustment is necessary when dotinurad is administered to patients with mild to moderate renal impairment.
Administration
Contra Indications
Hypersensitivity
Precautions
Pregnancy-Lactation
Pregnancy
There are no available human data on use in pregnant women to inform a drug-associated risk.
Lactation
Unknown if distributed in human breast milk It is present in the milk of rats
Interactions
Adverse Effects
Side effects of Dotinurad :
The most commonly reported adverse reactions include gouty arthritis, arthritis and discomfort in limbs.
Increased creatinine and Nephrolithiasis were reported.
Mechanism of Action
Dotinurad, a selective urate reabsorption inhibitor (SURI), potently inhibits urate transporter 1 (URAT1) but minimally inhibits ATP-binding cassette subfamily G member 2 (ABCG2), organic anion transporter 1 (OAT1), and OAT3.
Note
Dotiric 0.5 mg Tablet manufactured by Everest Pharmaceuticals Ltd.. Its generic name is Dotinurad. Dotiric is availble in Bangladesh.
Farmaco BD drug index information on Dotiric Tablet is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.