Oxymetazoline eye prep
Indications
Oxymetazoline eye prep is used for:
Blepharoptosis
Adult Dose
Eye drop
Adult
Indicated for acquired blepharoptosis in adults
Instill 1 drop to the affected eye(s) once daily
Child Dose
Renal Dose
Administration
Contra Indications
Precautions
Alpha-adrenergic agonists may impact blood pressure; caution with severe or unstable cardiovascular disease, orthostatic hypotension, and uncontrolled hypertension or hypotension
Caution with cerebral insufficiency, coronary insufficiency, or Sjögren syndrome
May increase risk of angle-closure glaucoma in patients with untreated narrow-angle glaucoma
Advise patients to seek medical care if signs and symptoms of cardiovascular disease, vascular insufficiency, or acute angle-closure glaucoma develop
Ptosis may be associated with neurologic or orbital diseases such as stroke and/or cerebral aneurysm, Horner syndrome, myasthenia gravis, external ophthalmoplegia, orbital infection and orbital masses; give consideration to these conditions in the presence of ptosis with decreased levator muscle function and/or other neurologic signs
Pregnancy-Lactation
Pregnancy
Data are not available regarding use during pregnancy to inform a drug-associated risk for major birth defects and miscarriage
Animal studies
No adverse developmental effects observed after oral administration in pregnant rats and rabbits at systemic exposures up to 7 and 278 times the maximum recommended human ophthalmic dose
Lactation
Data are unavailable to assess effects on breastmilk quantity or production, or to establish the level of oxymetazoline present in human breastmilk
Interactions
Alpha-adrenergic agonists, as a class, may impact blood pressure; caution if coadministered with beta-blockers, antihypertensives, and/or cardiac glycosides
Caution in patients taking MAO inhibitors, which can affect metabolism and uptake of circulating amines
Adverse Effects
Side effects of Oxymetazoline eye prep :
1-10%
Punctate keratitis (1-5%)
Conjunctival hyperemia (1-5%)
Dry eye (1-5%)
Blurred vision (1-5%)
Instillation site pain (1-5%)
Eye irritation (1-5%)
Headache (1-5%)
Mechanism of Action
Alpha-adrenergic agonist
Targets a subset of adrenoreceptors in Mueller muscle of the eyelid for use to treat acquired blepharoptosis