Dapsone
Indications
Dapsone is used for:
Pneumonia, Acne, Leprosy, Dermatitis herpetiformis
Adult Dose
Oral
Dermatitis Herpetiformis
50 mg once daily, titrate to 300 mg once daily or higher to achieve the desired effect
Reduce dose to the minimum effective dose within the range of 50-300 mg once daily as soon as possible
Leprosy
100 mg once daily, in combination with other antileprosy drugs
Tuberculoid or Lepromatous Disease
100 mg once daily with rifampin 600 mg once daily
Child Dose
Child:
Oral
Leprosy
1-2 mg/kg once daily; not to exceed 100 mg/day in combination with other antileprosy agents
2 mg/kg, max 100 mg once daily
4 mg/kg, max 200 mg Once weekly
Renal Dose
Administration
Contra Indications
Hypersensitivity. Severe anaemia, porphyria.
Precautions
May cause blood dyscrasias (eg, agranulocytosis); monitor closely
Peripheral neuropathy may occur
Toxic epidermal necrolysis and other dermatologic reactions may occur
Use caution when treating patients with hypersensitivity to sulfonamides
Bacterial and fungal superinfections may occur from prolonged treatments
Pregnancy-Lactation
Pregnancy category: C
Lactation: Enters breast milk; not recommended (AAP Committee states "compatible with nursing")
Interactions
Decreased serum conc of dapsone when used with rifampicin.
Increased plasma conc with probenecid, trimethoprim.
Antagonize clofazimine.
Contraindicated (0)
Serious (19)
aluminum hydroxide
apalutamide
BCG vaccine live
calcium carbonate
dapsone topical
famotidine
fexinidazole
ibuprofen/famotidine
idelalisib
ivosidenib
lansoprazole
lonafarnib
mefloquine
nefazodone
selinexor
sodium bicarbonate
sodium citrate/citric acid
tucatinib
typhoid vaccine live
Adverse Effects
Side effects of Dapsone :
1-10%
Hemolysis,Methemoglobinemia
<1%
Reactional states (ie, abrupt changes in clinical activity occurring during any leprosy treatment; classified as reversal of erythema nodosum leprosum reactions),Insomnia,Headache,Exfoliative dermatitis,Photosensitivity,Nausea,Vomiting,Anemia,Leukopenia,Agranulocytosis,Hepatitis,Cholestatic jaundice,Peripheral neuropathy (usually in nonleprosy patients),Blurred vision,Tinnitus,SLE
Potentially Fatal: Agranulocytosis, serious cutaneous hypersensitivity reactions, exfoliative dermatitis.
Mechanism of Action
Dapsone inhibits folic acid synthesis by preventing normal bacterial utilization of PABA (PABA).