Calcium Acetate

Indications

Calcium Acetate is used for: Hyperphosphatemia

Adult Dose

Hyperphosphatemia in End Stage Renal Failure (On Dialysis) Initial: 2 capsules (1334 mg) PO with each meal Increase dose to bring serum phosphate value <6 mg/dL as long as hypercalcemia does not develop Usual Dose: 3-4 capsules (2001-2868 mg) PO with each meal

Child Dose

Renal Dose

Administration

Should be taken with food.

Contra Indications

Patients with hypercalcaemia.

Precautions

Constipation may occur Cardiac glycosides; hypercalcemia may aggravate digitalis toxicity Advise patients to limit intake of oxalate-rich foods (soy, green leafy vegetables, animal protein) to avoid Ca-Oxalate formation Patients with end-stage renal disease may develop hypercalcemia when treated with calcium; avoid concurrent use of calcium supplements, including calcium-based nonprescription antacids Monitor Early in the treatment phase during the dosage adjustment period, monitor serum calcium levels twice weekly

Pregnancy-Lactation

Pregnancy Category: C Maintenance of normal serum calcium levels is important for maternal and fetal well being; hypercalcemia during pregnancy may increase risk for maternal and neonatal complications(eg, stillbirth, preterm delivery, neonatal hypocalcemia and hypoparathyroidism);calcium acetate treatment, as recommended, is not expected to harm a fetus if maternal calcium levels are properly monitored during and following treatment Lactation: unknown

Interactions

Tetracycline antibiotics, thiazide diuretics, vit D, corticosteroids, bisphosphonates, fluoride, some fluoroquinolones. Contraindicated (1) ceftriaxone Serious (8) baloxavir marboxil demeclocycline doxycycline eltrombopag erdafitinib minocycline oxytetracycline tetracycline

Adverse Effects

Side effects of Calcium Acetate : Frequency Not Defined Arrhythmias Hypomagnesemia Hypophosphatemia Hypotension Nausea Pruritus (rare) Weakness Hypercalcemia Anorexia Coma Confusion Delirium Headache Nausea Vomiting

Mechanism of Action

Sequesters phosphate in the intestine by forming insoluble phosphates that are excreted faecally, thus reducing serum phosphate conc & secondary hyperparathyroidism.