Zilapro Powder for Suspension
Cefprozil
250mg/5ml
Beximco Pharmaceuticals Ltd.
| Pack size | 56ml bot |
|---|---|
| Dispensing mode | |
| Source | |
| Agent | |
| Retail Price | 276 AED |
Available as:
Indications
Zilapro Powder for Suspension is used for:
Pharyngitis, Susceptible infections, Sinusitis, Otitis media, Skin and skin structure infections, Tonsillitis, Respiratory tract infections, Acute Maxillary Sinusitis, Acute bacterial exacerbation of chronic bronchitis
Adult Dose
Pharyngitis & Tonsillitis
500 mg PO once daily for 10 days
Respiratory Tract Infections, Skin Infections
250-500 mg twice daily OR
500 mg once daily for10 days
Child Dose
Child:
PO 15–30 mg/kg/day q12h
Acute Otitis Media
6 months old-12 years old: 30 mg/kg/day divided q12hr PO x 10 days
Acute Sinusitis
6 months old-12 years old: 15-30 mg/kg/day divided q12hr PO x10 days
Pharyngitis & Tonsillitis
2-12 years old: 15 mg/kg/day divided q12hr PO x10 days
Skin Infections
2-12 years old: 20 mg/kg PO qDay x10 days
>12 years
Pharyngitis & Tonsillitis
500 mg PO once daily for 10 days
Respiratory Tract Infections, Skin Infections
250-500 mg twice daily OR
500 mg once daily for10 days
Renal Dose
Renal impairment:
CrCl (ml/min)
<30 Half normal dose.
Administration
May be taken with or without food. May be taken w/ meals to reduce GI discomfort.
Contra Indications
Hypersensitivity.
Precautions
Oral suspension contains aspartame; not indicated for patients with phenylketonuria
Careful inquiry should be made to determine if patient has had previous hypersensitivity to cephalosporins, penicillins or similar drugs; cross sensitivity reported among beta-lactam antibiotics; discontinue therapy if reaction occurs
Hypersensitivity reactions may require treatment with epinephrine and emergency measures, including intravenous fluids, oxygen, corticosteroids, intravenous antihistamines, pressor amines, and airway management as indicated
Prescribing antibiotics in the absence of proven or strongly suspected bacterial infection or a prophylactic indication is unlikely to provide benefit to patient and increases risk of development of drug-resistant bacteria
Prolonged use of therapy may result in overgrowth of nonsusceptible organisms; careful observation of patient essential; if superinfection occurs during therapy, appropriate measures should be taken
Cefprozil should be prescribed with caution in individuals with a history of gastrointestinal disease particularly colitis
Positive direct Coombs’ tests have been reported during treatment with cephalosporin antibiotics.
Monitor renal and haematologic status.
Pregnancy-Lactation
Pregnancy Category: B
Lactation: low distribution into breast milk; use with caution
Interactions
Renal excretion delayed by probenecid.
Decreases contraceptive effect of oestrogen-containing oral contraceptives.
Contraindicated (0)
Serious (4)
BCG vaccine live
cholera vaccine
microbiota oral
typhoid vaccine live
Adverse Effects
Side effects of Cefprozil :
1-10%
Nausea (3.5%),Diarrhea (2.9%),Elevated LFTs (2%),Diaper rash (1.5%),Abdominal pain (1%),Dizziness (1%),Vomiting (1%)
<1%
Eosinophilia,Superinfection,Vaginitis,Cholestatic jaundice,Elevated BUN & creatinine,Prolonged PT
Potentially Fatal: Pseudomembranous colitis.
Mechanism of Action
Cefprozil inhibits cell wall synthesis and has activity against a broad range of gram-positive and gram-negative bacteria.
Note
Zilapro 250mg/5ml Powder for Suspension manufactured by Beximco Pharmaceuticals Ltd.. Its generic name is Cefprozil. Zilapro is availble in Bangladesh.
Farmaco BD drug index information on Zilapro Powder for Suspension is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.