Xovir 400 Tablet
Acyclovir Oral
400mg
Beacon Pharmaceuticals Ltd.
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| Retail Price | 22.00 AED |
Available as:
Indications
Xovir 400 Tablet is used for:
Herpes simplex infections, Varicella zoster (chickenpox), Herpes zoster (shingles), Genital herpes
Adult Dose
Oral
Primary herpes simplex infections
Adult: 200 mg 5 times daily every 4 hr (omitting the night time dose) for 5-10 days;
For severely immuno compromised patients and those with impaired absorption
400 mg 5 times daily for 5 days.
Suppression of recurrent herpes simplex in immunocompetent patients
Adult: 800 mg daily in 2-4 divided doses. (400 mg 2 times daily OR 200 mg 4 times daily)
May reduce to 400-600 mg daily if necessary. Reassess the condition every 6-12 mth.
For mild or infrequent recurrences: Episodic treatment may be used: 200 mg 5 times daily for 5 days, preferably begun during the prodromal period.
Prophylaxis of herpes simplex in immunocompromised patients
Adult: 200 mg 4 times daily.
In severely immunocompromised patients (eg after marrow transplant) or in patients with impaired absorption from the gut
400mg 4 times daily.
Varicella Zoster (Chickenpox)
800 mg 5 times/day for 5-7 days.
Herpes zoster (shingles)
800 mg 5 times/day for 7-10 days.
Child Dose
Oral
Primary herpes simplex infections
Children >2 years:
200 mg 5 times daily every 4 hr (omitting the night time dose) for 5-10 days;
For severely immuno compromised patients and those with impaired absorption
400 mg 5 times daily for 5 days.
Children <2 years
Half of the adult dose.
Suppression of recurrent herpes simplex in immunocompetent patients
Children >2 years
800 mg daily in 2-4 divided doses. (400 mg 2 times daily OR 200 mg 4 times daily)
May reduce to 400-600 mg daily if necessary. Reassess the condition every 6-12 mth.
Children <2 years
Half of the adult dose.
Prophylaxis of herpes simplex in immunocompromised patients
Children >2 years
200 mg 4 times daily.
In severely immunocompromised patients (eg after marrow transplant) or in patients with impaired absorption from the gut
400mg 4 times daily.
Children <2 years
Half of the adult dose.
Varicella Zoster (Chickenpox)
Children >2 years and <40 kg:
20 mg/kg/dose PO 4 times daily (80 mg/kg/day) for 5 days; not to exceed 800 mg/dose
Children over 40 kg: 800 mg 4 times daily for 5-7 days.
Children aged 2-5 years
400mg 4 times daily for 5 days.
Children aged 6 years and over
800mg 4 times daily for 5 days.
Dosing may be more accurately calculated as 20mg/kg bodyweight (not to exceed 800mg four times daily).
Renal Dose
Renal impairment (PO)
Normal dosage 200 mg q4hr or 400 mg q12hr and CrCl <10 mL/min/1.73 m²: Decrease to 200 mg q12hr
Normal dosage 800 mg q4hr and CrCl 10-25 mL/min/1.73 m²: Decrease to 800 mg q8hr
Normal dosage 800 mg q4hr and CrCl <10 mL/min/1.73 m²: Decrease to 800 mg q12hr
Administration
May be taken with or without food. May be taken w/ meals to reduce GI discomfort.
Contra Indications
Hypersensitivity.
Precautions
Renal impairment. Pregnancy, lactation. Neurological abnormalities with significant hypoxia, serious hepatic or electrolyte abnormalities.
Maintain adequate hydration.
Pregnancy-Lactation
Pregnancy category: B
Lactation: Drug enters breast milk; use with caution
Interactions
Probenecid, cimetidine and mycophenolate mofetil may increase the plasma concentration of aciclovir. Increased nephrotoxic effects w/ drugs that affect renal physiology (e.g. ciclosporin, tacrolimus).
Contraindicated (0)
Serious - Use Alternative (5)
amphotericin B deoxycholate
bacitracin
cidofovir
neomycin PO
talimogene laherparepvec
Adverse Effects
Side effects of Acyclovir Oral :
>10%
Oral
Malaise (<12%)
1-10%
Oral
Nausea (2-5%),Vomiting (<3%),Diarrhea (2-3%),Headache (2%)
<1%
Abdominal pain,Aggression/confusion,Agitation,Alopecia,Anaphylaxis,Anemia,Angioedema,Anorexia,Ataxia,Coma,Disseminated intravascular coagulation (DIC),Dizziness,Fatigue
Potentially Fatal: Occasionally neurotoxicity after IV use: Lethargy, confusion, agitation, tremors, seizures, coma.
Mechanism of Action
Activity against HSV types I and II and varicella-zoster virus is due to intracellular conversion of aciclovir to the monophosphate by viral thymidine kinase with subsequent conversion to the diphosphate and active triphosphate by cellular enzymes. This active form inhibits viral DNA synthesis and replication by interfering with viral DNA polymerase enzyme and being incorporated into viral DNA.
Note
Xovir 400 400mg Tablet manufactured by Beacon Pharmaceuticals Ltd.. Its generic name is Acyclovir Oral. Xovir 400 is availble in Bangladesh.
Farmaco BD drug index information on Xovir 400 Tablet is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.