Xfin Cream
Terbinafine Topical
1gm/100gm
Square Pharmaceuticals PLC.
| Pack size | 10gm tube |
|---|---|
| Dispensing mode | |
| Source | |
| Agent | |
| Retail Price | 80.00 AED |
Indications
Xfin Cream is used for:
Tinea pedis, Tinea cruris, Tinea corporis, Dermatophytosis, Nail infections, Cutaneous candidiasis, Pityriasis versicolor
Adult Dose
Topical/Cutaneous
As cream or spray
Dermatophytosis
Adult:
Tinea Pedis: Apply to affected area BID until significant clinical improvement (no more than 4 weeks)
Tinea Corporis & Cruris: Apply once daily, for 1 week, (no more than 4 weeks)
Cutaneous candidiasis and pityriasis versicolor: Apply once or bid for 2 wk
As spray
Dermatophytosis
Terbinafine 1% Spray: This spray is applied once or twice daily, depending on the indication.
Tinea pedis: once a day,1 week
Tinea corporis/cruris: once a day,1 week
Pityriasis Versicolor: twice a day, 1 week
Child Dose
Not FDA approved for peds
Renal Dose
Administration
Contra Indications
Hypersensitivity, active or chronic liver disease, lactation.
Precautions
Preexisting liver or renal impairment, pregnancy. Perform liver function tests prior to oral therapy.
Lactation: not safe for nursing infants
Pregnancy-Lactation
Pregnancy Category: B
Lactation: not safe for nursing infants
Interactions
Possible increase in levels in drugs metabolised by CYP450 2D6. Decreased terbinafine concentration with rifampicin; increased terbinafine concentration with cimetidine.
Adverse Effects
Side effects of Terbinafine Topical :
1-10%
Burning,Contact dermatitis,Dryness,Exfoliation,Irritation,Pruritus,Rash,Irritation,Stinging
Potentially Fatal: Liver failure, Stevens-Johnson syndrome, neutropaenia.
Mechanism of Action
Terbinafine causes fungal cell death by inhibiting squalene epoxidase, the main enzyme in sterol biosynthesis, resulting in ergosterol deficiency within fungal cell walls. It has fungicidal activity against dermatophytes and some yeast.
Note
Xfin 1gm/100gm Cream manufactured by Square Pharmaceuticals PLC.. Its generic name is Terbinafine Topical. Xfin is availble in Bangladesh.
Farmaco BD drug index information on Xfin Cream is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.