Vtapa Cream
Tapinarof topical
1 gm/100 gm
Synovia Pharma PLC
| Pack size | 30 gm tube |
|---|---|
| Dispensing mode | |
| Source | |
| Agent | |
| Retail Price | 1500.00 AED |
Indications
Vtapa Cream is used for:
Plaque Psoriasis
Adult Dose
Topical
Plaque Psoriasis
Apply a thin layer to affected areas once daily
Child Dose
Renal Dose
Administration
Topical Administration
Apply to skin lesions only, and wash hands after application unless treating hands
Use only externally
Contra Indications
Precautions
Apply the medication to skin lesions only, and avoid unaffected areas of skin
Advise patients that medication is for external use only
Pregnancy-Lactation
Pregnancy
Available data in pregnant women are insufficient to evaluate for drug-associated risk of major birth defects, miscarriage, or other adverse maternal or fetal outcomes
Animal data
In animal reproduction studies, subcutaneous administration of tapinarof to pregnant rats and rabbits during the period of organogenesis resulted in no significant adverse effects at doses 268 and 16 times, respectively, the maximum recommended human dose (MRHD)
Lactation
No data available regarding presence of drug in human milk, effects on breastfed infant, or on milk production; drug was detected in rat offspring following subcutaneous administration to pregnant female rats, which suggest that drug was transferred into milk of lactating rats; when drug is present in animal milk, it is likely that the drug will be present in human milk
Developmental and health benefits of breastfeeding should be considered along with mother’s clinical need for therapy and any potential adverse effects on breastfed infant from therapy or from underlying maternal condition
Interactions
Adverse Effects
Side effects of Tapinarof topical :
>10%
Folliculitis (20%)
Nasopharyngitis, including nasal congestion, pharyngitis, respiratory tract infection (RTI) viral, rhinorrhea, sinus congestion, upper RTI, and viral upper RTI (11%)
1-10%
Contact dermatitis, including dermatitis, hand dermatitis, and rash (7%)
Headache, including migraine and tension headache (4%)
Pruritus, including application site pruritus, generalized pruritus, and genital pruritus (3%)
Influenza, including influenza-like illness (2%)
Mechanism of Action
Aryl hydrocarbon receptor (AhR) agonist; efficacy of tapinarof in psoriasis is attributed to its binding and activation of the aryl hydrocarbon receptor (AhR), a ligand-dependent transcription factor, leading to the downregulation of proinflammatory cytokines, including interleukin 17
Note
Vtapa 1 gm/100 gm Cream manufactured by Synovia Pharma PLC. Its generic name is Tapinarof topical. Vtapa is availble in Bangladesh.
Farmaco BD drug index information on Vtapa Cream is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.