Virunil Cream
Acyclovir 5% Topical
5 gm/100 gm
Globe Pharmaceuticals Ltd.
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| Retail Price | 70.00 AED |
Indications
Virunil Cream is used for:
Herpes virus infections of skin
Adult Dose
As 5% oint/cream:
Adult:
Apply to the affected skin 5 times a day for 5–10 days, to be applied to lesions approximately every 4 hours, starting at first sign of attack
Child Dose
Child:
Apply 5 times a day for 5–10 days, to be applied to lesions approximately every 4 hours, starting at first sign of attack
Renal Dose
Administration
Contra Indications
Hypersensitivity.
Precautions
Renal impairment. Pregnancy, lactation. Neurological abnormalities with significant hypoxia, serious hepatic or electrolyte abnormalities. Maintain adequate hydration.
Lactation: Excretion in milk unknown; systemic exposure is minimal after topical application.
Pregnancy-Lactation
Pregnancy category: B
Lactation: Excretion in milk unknown; systemic exposure is minimal after topical application
Interactions
Probenecid, cimetidine and mycophenolate mofetil may increase the plasma concentration of aciclovir. Increased nephrotoxic effects w/ drugs that affect renal physiology (e.g. ciclosporin, tacrolimus).
Adverse Effects
Side effects of Acyclovir 5% Topical :
>10%
Burning/stinging (30%)
1-10%
Pruritus (4%)
<1%
Dry lips (<1%),Rash (0.3%)
Frequency Not Defined
Angioedema,Vulvitis
Mechanism of Action
Activity against HSV types I and II and varicella-zoster virus is due to intracellular conversion of aciclovir to the monophosphate by viral thymidine kinase with subsequent conversion to the diphosphate and active triphosphate by cellular enzymes. This active form inhibits viral DNA synthesis and replication by interfering with viral DNA polymerase enzyme and being incorporated into viral DNA.
Note
Virunil 5 gm/100 gm Cream manufactured by Globe Pharmaceuticals Ltd.. Its generic name is Acyclovir 5% Topical. Virunil is availble in Bangladesh.
Farmaco BD drug index information on Virunil Cream is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.