Topicacin Cream
Capsaicin 0.025% topical
25 mg/100 gm
Incepta Pharmaceuticals Ltd.
| Pack size | 20gm tube |
|---|---|
| Dispensing mode | |
| Source | |
| Agent | |
| Retail Price | 50.00 AED |
Indications
Topicacin Cream is used for:
Rheumatoid arthritis, Osteoarthritis, Psoriasis, Post-herpetic neuralgia, Anogenital pruritus, Sprains, Stiff neck, Low back pain, Trigeminal neuralgia, Spondylitis, Peripheral neuralgias:, Diabetic neuropathy, Post-surgical pains
Adult Dose
Skeletomuscular Pain
Apply to the affected area three/four times daily for 3-4 consecutive weeks and evaluate efficacy;
Efficacy decreased if used < 3 times daily; not to exceed 4 applications/day;
Child Dose
Safety & efficacy not established
Renal Dose
Administration
Apply a thin film of Capsaicin cream to affected area. A burning sensation may occur upon application, but generally disappears with regular use. Wash hands with soap and water after applying.
Contra Indications
Capsaicin cream is contraindicated for use on broken or irritated skin or known hypersensitivity to this medication.
Precautions
Do not apply to face or scalp to avoid exposure to eyes or mucous membranes
Transient burn sensation may occur but generally disappears after several days
Not for use immediately before or after activities such as, swimming, showering, bathing, strenuous exercise, sunbathing, sauna, steam bath, or other types of heat, or exposure to sunlight to treated areas
Accidental exposure to eyes and mucous membranes can occur from touching drug product or items exposed to drug product and then touching eyes and mucous membranes
If irritation of eyes or mucous membranes occurs, flush eyes and mucous membranes with cool water
First, to third-degree chemical Burns may occur upon application; discontinue use and seek medical attention if signs of skin injury, including pain, blistering, or swelling occurs
Do not handle contact lenses for at least 1 hr after handling drug product
Use caution in patients with uncontrolled hypertension, history of cerebrovascular events
Pregnancy-Lactation
Pregnancy Category: B
Lactation: Unknown whether distributed in breast milk; do not apply to nipple or areola
Interactions
Capsaicin, including topical use, may cause or exacerbate coughing associated with ACE inhibitor treatment and vice versa. If a severe cough develops in patients taking an ACE inhibitor and using capsaicin, 1 or both drugs may need to be discontinued.
Adverse Effects
Side effects of Capsaicin 0.025% topical :
>10%
Transient increased pain at application site (dissipates w/ continued use),Application site erythema (63%),Pain (42%)
1-10%
Nausea (5%),Vomiting (3%),Hypertension (2%),Dryness (2%),Swelling (2%),Pruritus (6%),Papules (6%),Edema (4%),Sinusitis (3%),Bronchitis (2%)
<1%
Exfoliation,Dizziness,Cough,Skin odor,Headache,Dysguesia
Mechanism of Action
Transient receptor potential vanilloid-1 (TRPV1) agonist; topical application causes initial TRPV1 stimulation that may cause pain, followed by pain relief by reduction in TRPV1-expressing nociceptive nerve endings
Note
Topicacin 25 mg/100 gm Cream manufactured by Incepta Pharmaceuticals Ltd.. Its generic name is Capsaicin 0.025% topical. Topicacin is availble in Bangladesh.
Farmaco BD drug index information on Topicacin Cream is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.