Thalidon Tablet

Thalidon Tablet is used for: Hypertension, Oedema, Diabetes insipidus, Congestive heart failure

Hypertension 25-100 mg/day PO; usual range, 12.5-25 mg/day Edema 50-100 mg/day PO or 100 mg PO every other day; not to exceed 200 mg/day Heart Failure 12.5-25 mg/day PO; not to exceed 100 mg/day

Renal impairment CrCl <10 mL/min: Ineffective; do not use CrCl >10 mL/min: Dose adjustment not necessary

Should be taken with food. Take during meals.

Severe renal impairment or anuria. Severe hepatic impairment, addison's disease, preexisting hypercalcaemia, asthma; hypersensitivity; severe allergy. Pregnancy and lactation.

Therapy may alter glucose tolerance; raise serum levels of cholesterol and triglycerides, raise the serum uric acid level due to reduced clearance of uric acid and may cause or exacerbate hyperuricemia and precipitate gout in susceptible patients; drug decreases urinary calcium excretion and may cause elevations of serum calcium; monitor calcium levels in patients with hypercalcemia receiving therapy Use with caution in diabetes mellitus, fluid or electrolyte imbalance, hypercholesterolemia, hypotension, systemic lupus erythematosus, liver disease, severe renal disease, advanced age, history of allergy or bronchial asthma Use with caution in patients with hyperuricemia or gout; gout can be precipiated in patients with history of gout, familial predisposition to gout or chronic renal failure; risk can be increased with doses ≥25 mg (in hydrochlorothiazide equivalents) Avoid concurrent use with lithium (reduction of lithium dosage by 50% may be necessary) May aggravate digitalis toxicity Patients allergic to sulfa drugs may show cross-sensitivity; however, recent reports have suggested that cross reactivity between antibiotic sulfonamides and nonantibiotic sulfonamides may not occur or at very least, potential if extremely low Risk of male sexual dysfunction Photosensitization may occur Electrolyte disturbances (eg, hypokalemia, hyponatremia, hypochloremic alkalosis) may occur; electrolyte distrubances can be minimized when used in combination with electrolyte sparing antihypertensives (eg, ACE inhibitors or angiotensin receptor blockers); correct hypokalemia before initiating therapy; use with caution Avoid use of diuretics in the treatment of elevated blood pressure in patients with primary adrenal insufficiency; adjustment of glucocorticoid/ mineralocorticoid therapy and/or use of other antihypertensive agents should be considered to treat hypertension Prolonged use of thiazide diuretics reported to reduce calcium excretion; pathologic changes in parathyroid glands with hypercalcemia and hypophosphatemia reported with prolonged therapy Therapy may cause exacerbation or activation of systemic lupus erythematosus Monitor fluid and electrolyte balance.

Pregnancy Available data over decades from observational studies and reports with chlorthalidone use in pregnant women have not identified a drug-associated risk of major birth defects or miscarriage; however, adverse fetal outcomes, including fetal or neonatal jaundice, thrombocytopenia, hypoglycemia, and electrolyte abnormalities reported following maternal use of thiazide diuretics Drug not for use as first-line therapy to treat hypertension in pregnancy; advise pregnant women of potential risk to fetus Hypertension in pregnancy increases maternal risk for pre-eclampsia, gestational diabetes, premature delivery, and delivery complications (eg, need for cesarean section, and post-partum hemorrhage); hypertension increases fetal risk for intrauterine growth restriction and stillbirth Thiazides can cross placenta, and concentrations reached in umbilical vein approach those in maternal plasma; thiazides, like other diuretics, can cause placental hypoperfusion Use of thiazides during pregnancy associated with risk of fetal or neonatal jaundice, thrombocytopenia, hypoglycemia, and electrolyte abnormalities; thiazides do not prevent or alter course of EPH (Edema, Proteinuria, Hypertension) gestosis (pre-eclampsia) and should not be used as first-line therapy to treat hypertension in pregnant women Lactation Drug is present in human milk; there is no information regarding effects of on breastfed infant or on milk production; because of potential for drug accumulation which may lead to serious adverse reactions in breastfed infant (such as jaundice, thrombocytopenia, hyperglycemia, electrolyte abnormalities), advise patients that breastfeeding is not recommended during therapy

NSAIDs antagonise hypotensive action. Suppresses action of oral anticoagulants due to reduced prothrombin activity. Increased risk of hypokalaemia when corticosteroids are given concurrently. Potentially Fatal: Potentiates bone marrow suppression caused by anticancer drugs. Diuretic-induced vol depletion can potentiate aminoglycoside nephrotoxicity. Impairs action of oral hypoglycaemic agents. Enhances digitalis toxicity due to hypokalaemia. vol depletion enhances lithium toxicity, conversely, sudden withdrawal of diuretics may result in subtherapeutic levels of circulating lithium. Prolonged paralysis with tubocurarine due to hypokalemia. Contraindicated (0) Serious (8) aminolevulinic acid oral aminolevulinic acid topical isocarboxazid lofexidine methyl aminolevulinate squill tretinoin tretinoin topical

Side effects of Chlorthalidone : Common Cardiovascular: Hypotension, vasculitis Dermatologic: Photosensitivity, phototoxicity Endocrine/metabolic: Electrolyte abnormalities, hyperglycemia, hyperuricemia Gastrointestinal: Constipation, diarrhea, loss of appetite, nausea, vomiting Musculoskeletal: Spasticity Neurologic: Dizziness, headache, paresthesia Ophthalmologic: Blurred vision, xanthopsia Psychiatric: Restlessness Reproductive: Impotence Potentially Fatal: Rare. Severe hyponatraemia and idiosyncratic hypersensitivity.

Chlortalidone is an oral, long acting antihypertensive/diuretic. It is a monosulfamyl diuretic that acts by enhancing the excretion of sodium and chloride ions, and water by interfering with the transport of sodium ions across the renal tubular epithelium. Their primary site of action appears to be at the cortical diluting segment in the nephron of the loop of Henle.

Thalidon 25mg Tablet manufactured by Popular Pharmaceuticals Ltd.. Its generic name is Chlorthalidone. Thalidon is availble in Bangladesh. Farmaco BD drug index information on Thalidon Tablet is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.