Spacef Tablet
Cefditoren
400mg
General Pharmaceuticals Ltd.
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Available as:
Indications
Spacef Tablet is used for:
Pharyngitis, Community-acquired pneumonia, Susceptible infections, Tonsillitis, Soft tissue infections, Respiratory tract infections, Acute Exacerbations of Chronic bronchitis
Adult Dose
Oral
Community-acquired pneumonia
Adult: 400 mg bid for 14 days.
Acute bacterial exacerbation of chronic bronchitis
Adult: 400 mg bid for 10 days.
Pharyngitis ; Tonsillitis; Uncomplicated skin and skin structure infections
Adult: 200 mg bid for 10 days.
Child Dose
<12 years old: Safety & efficacy not established
>12 years old: As in adults
Renal Dose
Renal Impairment
CrCl 30-49 mL/minute/1.73 sq. meter: No more than 200 mg PO q12hr
CrCl <30 mL/minute/1.73/sq.meter: 200 mg PO qDay
End-stage: Dosing not established
Administration
Should be taken with food.
Contra Indications
Hypersensitivity to Cefditoren, other cephalosporins; or milk proteins. Carnitine deficiency.
Precautions
May cause diarrhea, nausea, and vaginal moniliasis (yeast infection); pseudomembranous colitis may occur; clinical manifestations of carnitine deficiency may occur with prolonged use; prolonged use may result in emergence and overgrowth of resistant organisms; caution in breastfeeding
Pregnancy-Lactation
Pregnancy Category: B
Lactation: excretion in milk unknown; use with caution
Interactions
Reduced oral bioavailability when coadministered with antacids or H2-receptor antagonists.
Probenecid may increase plasma concentration and prolong the half-life of Cefditoren.
May enhance the anticoagulant effect of vitamin K antagonists (e.g. warfarin).
Contraindicated (0)
Serious (3)
BCG vaccine live
cholera vaccine
microbiota oral
Adverse Effects
Side effects of Cefditoren :
>10%
Diarrhea (11-15%)
1-10%
Nausea (4-6%),Headache (2-3%),Abdominal pain (2%),Dyspepsia (1-2%),Vomiting (1%)
<1%
Bacterial/fungal superinfection,C. difficile colitis,Hypersensitivity,Increased bleeding time,Stevens-Johnson syndrome,Vaginal moniliasis
Potentially Fatal: Hypersensitivity, anaphylaxis, Stevens-Johnson syndrome, toxic epidermal necrolysis.
Mechanism of Action
Cefditoren is a third generation cephalosporin used for treatment of susceptible infections caused by gram-positive and gram-negative bacteria. It inhibits bacterial cell wall synthesis by binding to one or more of the penicillin-binding proteins (PBPs).
Note
Spacef 400mg Tablet manufactured by General Pharmaceuticals Ltd.. Its generic name is Cefditoren. Spacef is availble in Bangladesh.
Farmaco BD drug index information on Spacef Tablet is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.