Sitamax Tablet
Sitafloxacin
50 mg
Square Pharmaceuticals PLC.
| Pack size | 10's pack |
|---|---|
| Dispensing mode | |
| Source | |
| Agent | |
| Retail Price | 80.00 AED |
Indications
Sitamax Tablet is used for:
Laryngopharyngitis, tonsillitis, peritonsillar abscess, acute bronchitis, pneumonia, acute otitis media, sinusitis, chronic otitis media, chronic sinusitis, cystitis, pyelonephritis, complicated urinary tract infections (UTIs), urethritis, cervicitis, dental/oral infections: periodontitis, pericoronitis, osteitis of the jaw
Adult Dose
Adult
Standard dose: 50 mg twice daily or 100 mg once daily.
Treatment duration: varies by indication
3–7 days for laryngopharyngitis, tonsillitis, jaw infections
7 days for pneumonia or otitis/sinusitis
3 days for acute cystitis
7–14 days for pyelonephritis or complicated UTI
If poor response: may increase to 100 mg twice daily.
Child Dose
Renal Dose
Renal impairment
CrCl <50 mL/min): give 50 mg twice daily or 100 mg once daily.
CrCl 30–<50 mL/min: 50 mg once daily.
CrCl 10–<30 mL/min: 50 mg, with at least 48-hour interval between doses.
Administration
May be taken with or without food
Contra Indications
Known hypersensitivity to sitafloxacin or other quinolones.
Pregnancy and lactation.
Pediatric patients (infants, children, adolescents).
Precautions
Use with caution in patients with renal impairment (dose adjustment needed)
Patients with history of convulsions/epilepsy or neuromuscular conditions (e.g. Myasthenia gravis) — risk of CNS effects.
Risk of tendon disorders / tendon rupture, especially in elderly or with concomitant corticosteroid use.
May impair ability to drive or operate machinery (dizziness, CNS effects).
Pregnancy-Lactation
Pregnancy
Contraindicated. Sitafloxacin should not be used during pregnancy.
Breastfeeding
Avoid use during lactation; drug is excreted in milk (animal data) — nursing should be discontinued during therapy.
Interactions
Antacids containing Al or Mg, and drugs containing calcium or iron — reduce absorption of sitafloxacin.
NSAIDs (especially phenylacetic or propionic acid derivatives) — may increase risk of convulsions.
Concomitant corticosteroids — increases risk of tendon disorders/rupture.
Adverse Effects
Side effects of Sitafloxacin :
Common and serious adverse effects
Gastrointestinal: diarrhea, loose stools, abdominal pain, nausea.
Hepatic: elevated liver enzymes (ALT, AST, γ-GTP)
Dermatologic / hypersensitivity: rash, photosensitivity, serious reactions such as Stevens–Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), erythema multiforme.
Tendon disorders, tendon rupture.
CNS effects: convulsions, dizziness, headache.
Cardiac: QT prolongation, ventricular tachycardia in rare cases.
Blood dyscrasias (rare): agranulocytosis, pancytopenia, hemolytic anemia.
Others: interstitial pneumonia, rhabdomyolysis (very rare)
Others: interstitial pneumonia, rhabdomyolysis (very rare)
Mechanism of Action
Sitafloxacin is a fluoroquinolone antibiotic that exerts bactericidal activity by inhibiting bacterial DNA gyrase and topoisomerase IV, thereby blocking DNA replication and cell division. It has broad-spectrum activity including aerobic and anaerobic Gram-positive and Gram-negative bacteria, and atypical organisms.
Note
Sitamax 50 mg Tablet manufactured by Square Pharmaceuticals PLC.. Its generic name is Sitafloxacin. Sitamax is availble in Bangladesh.
Farmaco BD drug index information on Sitamax Tablet is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.