Seemacillin Oral Suspension
Ampicillin
125 mg/5 ml
Seema Pharmaceuticals Ltd.
| Pack size | 100 ml bot |
|---|---|
| Dispensing mode | |
| Source | |
| Agent | |
| Retail Price | 45.00 AED |
Available as:
Indications
Seemacillin Oral Suspension is used for:
Bacterial infections, Endocarditis, Typhoid fever, Community-acquired pneumonia, Uncomplicated gonorrhea, Susceptible infections, Bacterial meningitis, Paratyphoid fever, Septicaemia, Intrapartum prophylaxis against group B streptococcal infections
Adult Dose
Adult: PO
General Dosing Guidelines
PO: 250-500 mg q6hr
IV/IM: 1-2 g q4-6hr or 50-250 mg/kg/day divided q4-6hr; not to exceed 12 g/day
Susceptible infections 0.25-0.5 g 6 hrly.
Typhoid and paratyphoid fever 1-2 g 6 hrly. Duration: 2 wk (acute infections); 4-12 wk (carriers).
Uncomplicated gonorrhea W/ probenecid: 2 g as single dose.
IV/IM:
IV Intrapartum prophylaxis against group B streptococcal infections Initial, 2 g, then 1 g 4 hrly until delivery.
Septicaemia 150-200 mg/kg/day. Start with IV admin for 3 days, then IM inj 3-4 hrly.
Continue treatment for at least 48-72 hr after patient has become asymptomatic or when there is evidence of bacterial eradication.
IV/IM Susceptible infections 250-500 mg 6 hrly.
Meningitis 2-3 g 4-6 hrly, may start w/ IV admin, then continue w/ IM inj.
Inj Supplement to systemic therapy For intrapleural/intraperitoneal/intra-articular admin: 500 mg/day.
Gastrointestinal Tract Infections
<40 kg: 50 mg/kg/day IV/IM divided q6-8hr
>40 kg: 500 mg IV/IM q6hr; larger doses may be necessary in severe or chronic infection
Gonorrhea
3.5 g IV administered once simultaneously with 1 g of probenecid
Respiratory Tract Infections
>40 kg
250 mg PO q6hr
250-500 mg IV/IM q6hr
<40 kg
25 to 50 mg/kg/day IV or IM divided q6-8hr
Bacterial Meningitis/Septicemia
150-200 mg/kg/day IV divided q6-8hr; initiate with IV infusion; may continue with IM injections if preferred; range 6-12 g/day
Child Dose
Susceptible infections
Child:
PO: 50–100 mg/kg/day divided q6hr if <20
>20 kg 1–2 g/day divided q6hr
IV/IM:
Child: 50–200 mg/kg/day q6h
300–400 mg/kg/day endocarditis/meningitis q4–6h
General Dosing Guidelines
25-200 mg/kg/day IV/IM divided q6-8hr; not to exceed 12 g/day
50-100 mg/kg/day PO divided q6hr; not to exceed 2-4 g/day
Severe infection: 200-400 mg/kg/day IV/IM divided q6hr
Potential toxic dose <6 years: 300 mg/kg
Neonates (<28 Days)
<7 days
<2 kg: 50-100 mg/kg/day IV/IM divided q12hr
>2 kg: 75-150 mg/kg/day IV/IM divided q8hr
>7 days
<1.2 kg: 50-100 mg/kg/day IV/IM divided q12hr
1.2-2 kg: 75-150 mg/kg/day IV/IM divided q8hr
>2 kg: 100-200 mg/kg/day IV/IM divided q6hr
Endocarditis Treatment
300 mg/kg/day IV divided q4-6hr in combination with other antibiotics; not to exceed 12 g/day
Genitourinary Tract Infections
<40 kg: 50-100 mg/kg/day IV/IM divided q6hr
>40 kg: 500 mg IV/IM q6hr
Gastrointestinal Tract Infections
<20 kg: 50-100 mg/kg/day PO divided q6hr
>20 kg: 500 mg PO q6hr
<40 kg: 50 mg/kg/day IV/IM divided q6-8hr
>40 kg: 500 mg IV/IM q6hr
Gonorrhea
<20 kg: Safety and efficacy not established
>20 kg: 3.5 g PO administered once simultaneously with 1 g of probenecid
Respiratory Tract Infections
<20 kg: 50 mg/kg/day PO divided q6-8hr
>20 kg: 250 mg PO q6hr
<40 kg: 25-50 mg/kg/day IV/IM divided q6-8hr
>40 kg: 250-500 mg IV/IM q6hr
Bacterial Meningitis/Septicemia
150-200 mg/kg/day IV/IM divided q3-4hr; should initiate with IV infusion therapy and continued with IM injections if preferred
Soft Tissue Infections
<40 kg: 25-50 mg/kg/day IV/IM divided q6-8hr
>40 kg: 250-500 mg IV/IM q6hr
Community Acquired Pneumonia
< 3 months: Safety and efficacy not established
> 3 months:
Empiric treatment or S. pneumoniae
MICs to penicillin < 2 mcg/mL or H. influenzae (beta-lactamase negative, preferred: 150-200 mg/kg/day IV/IM divided q6hr
MICs to penicillin > 4 mg/mL; alternative to ceftriaxone: 300-400 mg/kg/day IV/IM divided q6hr
Group A Streptococcus
Moderate to severe (preferred): 200 mg/kg/day IVIM divided q6hr
Renal Dose
Renal impairment
CrCl <10 mL/min: Administer q12-24hr
CrCl 10-50 mL/min: Administer q6-12hr
CrCl >50 mL/min: Administer q6hr
Administration
Should be taken on an empty stomach. Take on an empty stomach 1 hr before or 2 hr after meals.
IV Preparation
Reconstitute with sterile water for injection or bacteriostatic water for injection
Use 5 mL for 125 mg, 250 mg, or 500 mg vials; 7.4 mL for 1 g vials; or 14.8 mL for 2 g vials
IV Administration
Use initial dilution within 1 hr
Give direct IV over 3-5 min for (125-500 mg) and over 10-15 minutes for larger doses (1-2 g)
Do not exceed a rate of 100 mg/min
For intermittent infusion, dilute in 50-100 mL of NS and give over 15-30 min
Give IV intermittently to prevent vein irritation (change site q48hr)
Contra Indications
Hypersensitivity; infectious mononucleosis.
Precautions
Use caution in allergy to cephalosporins, carbapenems
Adjust dose in renal failure; evaluate rash and differentiate from hypersensitivity reaction
Endocarditis prophylaxis: Use only for high-risk patients, per AHA Guidelines
Prolonged use associated with fungal or bacterial superinfection
Rash has developed during therapy in high percentage of patients with infectious mononucleosis receiving ampicillin class antibiotics; avoid therapy in these patients
Pregnancy-Lactation
Pregnancy category: B
Lactation: Excreted in breast milk; use caution
Interactions
May reduce the efficacy of OC. May alter INR while on warfarin and phenindione. May reduce the efficacy of oral typhoid vaccines. May reduce the excretion of methotrexate. Reduced excretion w/ probenecid and sulfinpyrazone, resulting to increased risk of toxicity. Allopurinol increases ampicillin-induced skin reactions. Reduced absorption w/ chloroquine. Bacteriostatic antibacterials (e.g. erythromycin, chloramphenicol, tetracycline) may interfere w/ the bactericidal action of ampicillin.
Contraindicated (0)
Serious - Use Alternative (13)
BCG vaccine live
cholera vaccine
demeclocycline
doxycycline
eravacycline
microbiota oral
minocycline
mycophenolate
omadacycline
oxytetracycline
sarecycline
tetracycline
typhoid vaccine live
Adverse Effects
Side effects of Ampicillin :
Frequency Not Defined
Erythema multiforme
Exfoliative dermatitis
Rash
Urticaria
Fever
Seizure
Black hairy tongue
Diarrhea
Enterocolitis
Glossitis
Nausea
Oral candidiasis
Pseudomembranous colitis
Stomatitis
Vomiting
Agranulocytosis
Anemia
Hemolytic anemia
Eosinophilia
Leukopenia
Thrombocytopenia purpura
Anaphylaxis
Aspartate aminotransferase increased
Interstitial nephritis
Laryngeal stridor
Serum sickness-like reaction
Potentially Fatal: Anaphylactic shock; pseudomembranous colitis; neuromuscular hypersensitivity; electrolyte imbalance.
Mechanism of Action
Ampicillin exerts bactericidal action on both gm+ve and gm-ve organisms. Its spectrum includes gm+ve organisms eg, S pneumoniae and other Streptococci, L monocytogenes and gm-ve bacteria eg, M catarrhalis, N gonorrhoea, N meningitidis, E coli, P mirabilis, Salmonella, Shigella, and H influenzae. Ampicillin exerts its action by inhibiting the synthesis of bacterial cell wall.
Note
Seemacillin 125 mg/5 ml Oral Suspension manufactured by Seema Pharmaceuticals Ltd.. Its generic name is Ampicillin. Seemacillin is availble in Bangladesh.
Farmaco BD drug index information on Seemacillin Oral Suspension is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.