Reelart Tablet
Desloratadine
5mg
Syntho Laboratories Ltd.
| Pack size | 50's pack |
|---|---|
| Dispensing mode | |
| Source | |
| Agent | |
| Retail Price | 2.50 AED |
Indications
Reelart Tablet is used for:
Itching, Sneezing, Watery eyes, Allergic conditions, Runny nose, Hives, Skin rash, Common cold, Allergic Rhinitis, Urticaria
Adult Dose
Oral
Allergic conditions, Allergic Rhinitis & Urticaria, Chronic Idiopathic Urticaria
Adult:
Tablet: 5 mg once daily.
Oral Solution - 2 teaspoonfuls (5 mg in 10 mL) once daily
Child Dose
Oral
Children 6 to 11 Months of Age:
Oral Solution - 2 mL (1 mg) once daily
Children 12 Months to 5 Years of Age:
Oral Solution - 1/2 teaspoonful (1.25 mg in 2.5 mL) once daily
Children 6 to 11 Years of Age:
Oral Solution - 1 teaspoonful (2.5 mg in 5 mL) once daily
Tablets - One 2.5 mg tablet once daily
Children 12 Years of Age and Over:
Tablets - one 5 mg tablet once daily
Oral Solution - 2 teaspoonfuls (5 mg in 10 mL) once daily
Renal Dose
Renal impairment: Initially, 5 mg every other day.
Administration
May be taken with or without food.
Contra Indications
Hypersensitivity to desloratadine or loratadine or components
Precautions
Caution in slow metabolizers; may increase incidence of side effects
Some products may contain sodium benzoate/benzoic acid (a metabolite of benzyl alcohol), associated with potentially fatal toxicity in neonates (gasping syndrome) when used in large amounts; some products may also contain phenylalanine
Use with caution in hepatic/renal impairment
Pregnancy-Lactation
Pregnancy
The limited available data in pregnant women are not sufficient to inform a drug-associated risk for major birth defects and miscarriage; there are no adequate and well-controlled studies in pregnant women
Reproductive potential
There are no data available on human infertility associated with desloratadine
Female: There were no clinically relevant effects of desloratadine on female fertility in rats
Male: A male specific decrease in fertility occurred at an oral desloratadine dose of ?12 mg/kg in rats (approximately 65 times the RHD); male fertility was unaffected at a desloratadine dose of 3 mg/kg (approximately 10 times the RHD)
Lactation
Desloratadine and pseudoephedrine both pass into breast milk; there are no sufficient data on effects of desloratadine on breastfed infant or effects of desloratadine on milk production
The decision should be made whether to discontinue nursing or to discontinue drug, taking into account developmental and health benefits of breastfeeding, the nursing mother’s clinical need, and any potential adverse effects on breastfed infant from therapy or from underlying maternal condition
Interactions
May potentiate effect of sedatives, including alcohol
Coadministration of desloratadine with ketoconazole, erythromycin, or azithromycin resulted in increased plasma concentrations of desloratadine and 3 hydroxydesloratadine, but no clinically relevant changes in safety profile of desloratadine reported
Coadministration of desloratadine with cimetidine, a histamine H2-receptor antagonist, resulted in increased plasma concentrations of desloratadine and 3 hydroxydesloratadine, but no clinically relevant changes in safety profile of desloratadine reported
Contraindicated (1)
thalidomide
Serious (29)
alfentanil
benzhydrocodone/acetaminophen
buprenorphine
buprenorphine buccal
buprenorphine subdermal implant
buprenorphine transdermal
buprenorphine, long-acting injection
codeine
erdafitinib
fentanyl
fentanyl intranasal
fentanyl iontophoretic transdermal system
fentanyl transdermal
fentanyl transmucosal
hydrocodone
hydromorphone
isocarboxazid
lasmiditan
methadone
metoclopramide intranasal
morphine
olopatadine intranasal
oxycodone
oxymorphone
remifentanil
sotorasib
tepotinib
tranylcypromine
zuranolone
Adverse Effects
Side effects of Desloratadine :
>10%
Headache (14%),Fever (12%),Irritability (12%),Diarrhea (15%),Upper respiratory infection (11%),Cough (11%)
1-10%
Dizziness (4%),Somnolence (2%),Dizziness (4%),Fatigue (2%),Erythema (2%),Macupopular rash (3%),Dysmenorrhea (2%),Urinary tract infection (4%),Bronchitis (6%),Epistaxis (3%)
Mechanism of Action
Desloratadine is a long-acting, tricyclic, non-sedating, selective peripheral histamine H1-receptor antagonist which inhibits the release of pro-inflammatory mediators from human mast cells and basophils.
Note
Reelart 5mg Tablet manufactured by Syntho Laboratories Ltd.. Its generic name is Desloratadine. Reelart is availble in Bangladesh.
Farmaco BD drug index information on Reelart Tablet is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.