Prelizer 5 Tablet
Bisoprolol
5mg
Radiant Pharmaceutical Ltd.
| Pack size | 28's pack |
|---|---|
| Dispensing mode | |
| Source | |
| Agent | |
| Retail Price | 10.00 AED |
Available as:
Indications
Prelizer 5 Tablet is used for:
Hypertension, Angina pectoris, Congestive heart failure
Adult Dose
Hypertension
The usual starting dose is 5 mg once daily. In some patients, 2.5 mg may be an appropriate starting dose.
If the antihypertensive effect of 5 mg is inadequate, the dose may be increased to 10 mg and then, if necessary, to 20 mg once daily.
Heart failure
Initially, 1.25 mg once daily (in the morning) for 1 week then, if well tolerated, increased to 2.5 mg once daily for 1 week, then 3.75 mg once daily for 1 week, then 5 mg once daily for 4 weeks, then 7.5 mg once daily for 4 weeks, then 10 mg once daily;
Max. 10 mg daily.
Child Dose
Renal Dose
Renal Impairment
>40 mL/min: Dose adjustment not necessary
<40 mL/min: 2.5 mg/day initially; titrate slowly and monitor
Administration
May be taken with or without food.
Contra Indications
Patients with cardiogenic shock, overt cardiac failure, second or third degree AV block and marked sinus bradycardia.
Precautions
Use caution in anesthesia/surgery (myocardial depression), bronchospastic disease, cerebrovascular insufficiency, CHF, cardiomegaly, DM, hyperthyroidism/thyrotoxicosis, myasthenia gravis, liver disease, renal impairment, peripheral vascular disease, use in pheochromocytoma, IDDM, history of psychiatric disease, pre-existing sick sinus syndrome or similar cardiac conditions
Chronically administered beta-blocking therapy should not be routinely withdrawn prior to major surgery; the impaired ability of the heart to respond to reflex adrenergic stimuli may augment the risks of general anesthesia and surgical procedures
Exacerbation of psoriasis reported with use
Less effective than thiazide diuretics in black and geriatric patients
Shown to decrease mortality in hypertension and post-myocardial infarction
Pregnancy-Lactation
Pregnancy Category: C
Lactation: excretion in milk unknown; use caution
Interactions
May potentiate AV conduction time and may increase negative inotropic effect w/ class I antiarrhythmic drugs (e.g. quinidine, disopyramide, propafenone). Concomitant catecholamine-depleting drugs (e.g. reserpine, guanethidine) may produce excessive sympathetic activity. May exacerbate rebound HTN upon discontinuance of clonidine treatment. Increased risk of bradycardia w/ digitalis glycosides. Reduced hypotensive effect w/ NSAIDs.
Contraindicated (0)
Serious (23)
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Adverse Effects
Side effects of Bisoprolol :
1-10%
Dizziness (10%),Dyssomnia (8%-10%),Bradyarrhythmia (9%),Upper respiratory infection (5%),Diarrhea (4%),Rhinitis (4%),Arthralgia (3%),Cough (3%),Dyspnea (2%),Nausea (2%),Pharyngitis (2%),Sinusitis (2%),Vomiting (2%)
<1%
Cold extremities,Hypotension,Depression,Dyspepsia,Bronchospasm
Frequency Not Defined
Aggravate CHF,Decrease HDL,Hypertriglyceridemia,Mask symptoms of hypoglycemia,Decreased exercise tolerance,Raynaud's phenomenon,May increase triglyceride levels and insulin resistance
Mechanism of Action
Bisoprolol selectively and competitively blocks beta1-receptors but has little or no effect on beta2-receptors except at high doses.
Note
Prelizer 5 5mg Tablet manufactured by Radiant Pharmaceutical Ltd.. Its generic name is Bisoprolol. Prelizer 5 is availble in Bangladesh.
Farmaco BD drug index information on Prelizer 5 Tablet is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.