Pilo Eye Drops
Pilocarpine Hydrochloride 1% Eye prep
Reman Drug Laboratories Ltd.
| Pack size | 10 ml drop/10 ml drop/10 ml drop |
|---|---|
| Dispensing mode | |
| Source | |
| Agent | |
| Retail Price | 74.20,172.25,212.00 AED |
Indications
Pilo Eye Drops is used for:
Open-angle glaucoma
Adult Dose
Ophthalmic
Open-angle glaucoma
Adult: Apply 1-2 drops into the affected eye/s up to 4 times daily, adjusted according to response.
Child Dose
Safety and efficacy not established
Renal Dose
Administration
Contra Indications
Angle-closure glaucoma; acute iritis, anterior uveitis; hypersensitivity. Pregnancy.
Precautions
Retinal detachment; corneal or conjunctival damage. Prolonged use may lead to lens opacities. May impair ability to drive or operate machines. Lactation.
Pregnancy-Lactation
Pregnancy
No adequate and well-controlled trials have been conducted in pregnant women
In a retrospective case series of 15 women with glaucoma, 4 patients used ophthalmic pilocarpine either prepregnancy, during pregnancy, or postpartum; there were no adverse effects observed in patients or in their infants
Animal studies
Oral administration to pregnant rats throughout organogenesis and lactation did not produce adverse effects at clinically relevant doses
Lactation
Unknown if excreted in human milk
Pilocarpine and/or its metabolites are excreted in the milk of lactating rats
Systemic levels of pilocarpine following topical ocular administration are low and it is not known whether measurable levels would be present in maternal milk following topical ocular administration
Interactions
Concomitant admin of 2 miotics may increase risk of toxic reactions. Aminoglycosides, clindamycin, colistin, cyclopropane and halogenated inhalational anaesthetics, quinine, procainamide, lithium and beta-blockers may reduce the efficacy of pilacarpine. Concurrent use with beta-blockers may lead to bradycardia. May prolong the action of suxamethonium.
Potentially Fatal: Miotic and ocular hypotensive effect antagonised by anticholinergics. Conduction disturbances with beta-blockers.
Adverse Effects
Side effects of Pilocarpine Hydrochloride 1% Eye prep :
1-10%
>5%
Headache/brow ache
Accommodative change
Blurred vision
Eye irritation
Visual impairment (dim, dark, or “jumping” vision)
Eye pain
Mechanism of Action
The drug acts through direct stimulation of muscarinic receptors and smooth muscle including the iris and secretory glands. Contracts the ciliary muscle, causing increased tension on scleral spur and opening of trabecular meshwork spaces to facilitate outflow of aqueous humor; outflow resistance is reduced, lowering intraocular pressure (IOP).
Also produces miosis through contraction of iris sphincter muscle; miosis relieves appositional angle narrowing and closure, which lowers IOP in certain types of angle-closure glaucoma
Note
Pilo Eye Drops manufactured by Reman Drug Laboratories Ltd.. Its generic name is Pilocarpine Hydrochloride 1% Eye prep. Pilo is availble in Bangladesh.
Farmaco BD drug index information on Pilo Eye Drops is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.