Perictol Tablet
Cyproheptadine HCI
4mg
Aexim Pharmaceuticals Ltd.
| Pack size | 100's pack |
|---|---|
| Dispensing mode | |
| Source | |
| Agent | |
| Retail Price | 2.00 AED |
Indications
Perictol Tablet is used for:
Rash, pruritus, appetite stimulation, anorexia nervosa, migraine, antidepressant-induced inorgasmia
Adult Dose
Oral
Allergic conditions
Symptomatic relief of allergy, such as hay fever, urticaria (Pruritus)
Adult: Initially, 4 mg tid, adjusted as necessary.
Usual: 12-16 mg daily in 3-4 divided doses.
Max: 32 mg/day.
Treatment and prophylaxis of migraine and other vascular headaches (Off-label)
Adult: 4 mg may be repeated after 30 min.
Not to exceed 8 mg w/in a 4- to 6-hr period.
Maintenance: 4 mg 4-6 hourly.
Decreased Appetite Secondary to Chronic Disease (Off-label)
2 mg 6 hourly for one week; THEN 4 mg 6 hourly
Drug-Induced Sexual Dysfunction (Off-label)
4-12 mg 1-2 hours before anticipated coitus or 1-16 mg/day
Child Dose
Oral
Allergic conditions
Child: 2-6 yr 2 mg bid or tid. Max: 12 mg daily;
7-14 yr 4 mg bid or tid. Max: 16 mg daily.
Migraine
Prophylaxis
< 3 years: Safety and efficacy not established
>3 years and adolescents: 0.2-0.4 mg/kg/day PO divided BID; not to exceed 0.5 mg/kg/day
Renal Dose
Administration
May be taken with or without food.
May be taken w/ meals to reduce GI discomfort.
Contra Indications
Documented hypersensitivity
Premature infants and neonates
Nursing women
Concomitant monoamine oxidase inhibitor therapy
Narrow-angle glaucoma
Stenosing peptic ulcer, pyloroduodenal obstruction
Symptomatic prostatic hypertrophy
Bladder neck obstruction
Elderly, debilitated patients
Precautions
Elimination reduced in renal insufficiency
Use with caution in cardiovascular disease, including hypertension
May cause CNS depression, which may impair mental abilities; use caution when operating heavy machinery
Use caution in cardiovascular disease, including hypertension and ischemic heart disease
Use with caution in patients with increased intraocular pressure, history of asthma or other chornic breathing disorders, or thyroid dysfunction
Nonanticholinergic antihistamines should be considered first for treatment of allergic reaction in the elderly (Beers criteria)
Antihistamines may cause excitation in young children
Pregnancy-Lactation
Pregnancy category: B
Lactation: Excretion in milk unknown; contraindicated
Interactions
May have additive effects w/ CNS depressants e.g. hypnotics, sedatives, tranquilizers, antianxiety agents.
Potentially Fatal: MAOIs prolong and intensify the anticholinergic effects of antihistamines.
Contraindicated (12)
isocarboxazid
linezolid
methylene blue
metyrapone
phenelzine
procarbazine
rasagiline
safinamide
selegiline
selegiline transdermal
tedizolid
tranylcypromine
Adverse Effects
Side effects of Cyproheptadine HCI :
Psychiatric/neurologic: CNS depression, drowsiness, sedation ranging from mild drowsiness to deep sleep (most frequent), dizziness, lassitude, disturbed coordination; less commonly, restlessness, insomnia, tremors, euphoria, nervousness, irritability, delirium, seizures, toxic psychosis, paresthesia
Muscular: Weakness
Cardiovascular: Palpitation, tachycardia, palpitation, ECG changes (eg, widened QRS), arrhythmias (eg, extrasystole, heart block), hypotension, hypertension, dizziness, sedation, hypotension
GI: Epigastric distress, anorexia, nausea, vomiting, diarrhea, constipation
Hepatic: Cholestasis, hepatitis, hepatic failure, hepatic function abnormality, jaundice (rare)
Skin: Eczema, pruritus, inflammation, papular rash, erythema on exposed skin
Sensory: Visual disturbances, blurred vision, diplopia, tinnitus, acute labyrinthitis
Renal: Dysuria, urinary retention
Respiratory: Thickening of bronchial secretions, wheezing, nasal stuffiness
Other: Vertigo, sweating, chills, early menses, headache, impotence, dryness of mouth, nose, and throat, facial dyskinesia, tightness of chest, faintness
Mechanism of Action
Cyproheptadine is a sedating antihistamine w/ antimuscarinic, serotonin antagonist and Ca channel blocking properties. It competes w/ histamine for H1-receptor sites on effector cells in the GI tract, blood vessels and resp tract.
Note
Perictol 4mg Tablet manufactured by Aexim Pharmaceuticals Ltd.. Its generic name is Cyproheptadine HCI. Perictol is availble in Bangladesh.
Farmaco BD drug index information on Perictol Tablet is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.