Pepto-Care Oral Solution

Bismuth subsalicylate

1.75 gm/100 ml

UniMed UniHealth Pharmaceuticals Ltd.

Pack size	200ml bot
Dispensing mode
Source
Agent
Retail Price	150.00 AED

Indications

Pepto-Care Oral Solution is used for: Diarrhea, nausea, heartburn, indigestion, upset stomach.

Adult Dose

Adult: 30 ml Diarrhea, Gas, Upset Stomach, Indigestion, Heartburn, Nausea 2 tablets (262 mg/tab) or 30 mL (regular strength) 3-4 times daily or as needed 30 minutes before meal. Maximum daily dose: 8 regular-strength doses or 4 extra-strength doses Traveler's Diarrhea Prophylaxis 2 tablets (262 mg/tab) 6 hourly for up to 3 weeks Helicobacter Pylori 525 mg (2 regular-strength tablets or 1 extra-strength tablet) + 250 mg metronidazole + 500 mg tetracycline 6 hourly for 14 days, plus an H2 antagonist

Child Dose

Child: Diarrhea, Gas, Upset Stomach, Indigestion, Heartburn, Nausea <3 years: Safety and efficacy not established 3-6 years: 1/3 tablet or 5 mL (regular strength) or 2.5 mL (extra strength) as needed 30 minutes before meal. 6-9 years: 2/3 tablet or 10 mL (regular strength) or 5 mL (extra strength) as needed 30 minutes before meal. 9-12 years: 1 tablet or 15 mL (regular strength) or 7.5 mL (extra strength) as needed 30 minutes before meal. >12 years: 2 tablets or 30 mL (regular strength) or 15 mL (extra strength) as needed 30 minutes before meal. Maximum daily dose: 8 regular-strength doses or 4 extra-strength doses Chronic Infantile Diarrhea <2 years: 2.5 mL (regular strength) 4 hourly 2-4 years: 5 mL (regular strength) 4 hourly 4-6 years: 10 mL (regular strength) 4 hourly

Renal Dose

Renal impairment: Overdose may cause nephrotoxicity

Administration

Drink plenty of clear fluids to prevent dehydration caused by diarrhea Do not use for >2 days

Contra Indications

Hypersensitivity to bismuth, aspirin, other salicylates. Infectious diarrhea, high fever, von Willebrand disease, hemorrhage, ulcer or GI bleeding with black or bloody stool, hemophilia. In pediatric patients, chicken pox or influenza (risk of Reye syndrome); changes in behavior with nausea and vomiting may be early sign of Reye syndrome.

Precautions

Bismuth may cause temporary and harmless darkening of the tongue and/or black stools, generally reversible within several days after treatment stopped; stool darkening should not be confused with melena Bismuth absorbs x-rays and may interfere with x-ray diagnostic procedures of the gastrointestinal tract Cases of neurotoxicity associated with excessive doses of various bismuth-containing products reported; effects have been reversible with discontinuation of bismuth therapy Not to be administered to children or teenagers recovering from flu-like symptoms or chickenpox; increased incidence of Reye syndrome, associated with salicylate products

Pregnancy-Lactation

Pregnancy category: C; D in 3rd trimester Lactation: Salicylates enter breast milk; use with caution

Interactions

Contraindicated (1) dichlorphenamide Serious (7) demeclocycline doxycycline eluxadoline minocycline oxytetracycline tetracycline warfarin

Adverse Effects

Side effects of Bismuth subsalicylate : >10% Nausea (12%) 1-10% Diarrhea (7%),Abdominal pain (7%),Melena (3%),Upper respiratory tract infection (2%),Constipation (2%),Anorexia (2%),Vomiting (2%),Asthenia (2%),Discolored tongue (2%),Headache (2%),Dyspepsia (2%),Dizziness (2%),Stool abnormality (1%),Duodenal ulcer (1%),Sinusitis (1%),Taste perversion (1%),Flatulence (1%),GI hemorrhage (1%),Pain (1%),Insomnia (1%),Anal discomfort (1%),Paresthesia (1%) Frequency Not Defined Anxiety,Confusion,Depression,Tinnitus,Weakness,Gray-black stool,Impaction,Muscle spasm,Neurotoxicity (rare)

Mechanism of Action

Antimicrobial anti-inflammatory action (bismuth); antisecretory effect (salicylate).

Note

Pepto-Care 1.75 gm/100 ml Oral Solution manufactured by UniMed UniHealth Pharmaceuticals Ltd.. Its generic name is Bismuth subsalicylate. Pepto-Care is availble in Bangladesh. Farmaco BD drug index information on Pepto-Care Oral Solution is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.

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Peptofit ^{1.75 gm/200 ml}

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