Pediclor Syrup
Chloral Hydrate
143.3 mg
Beacon Pharmaceuticals Ltd.
| Pack size | 100ml |
|---|---|
| Dispensing mode | |
| Source | |
| Agent | |
| Retail Price | 200.00 AED |
Indications
Pediclor Syrup is used for:
Insomnia, Sedation, Anxiety
Adult Dose
Oral
Insomnia
Short-term treatment (maximum 2 weeks) of severe insomnia which is interfering with normal daily life and where other therapies (behavioural and pharmacologic) have failed
Adult:
The usual dose is 430-860 mg (15-30 ml of the 143mg/5ml strength).
Higher doses should not exceed a maximum of 2 g chloral hydrate (70 ml of the 143mg/5ml strength) per dose.
Child Dose
Oral
Insomnia
Short-term treatment (maximum 2 weeks) of severe insomnia in children and adolescents with suspected or definite neurodevelopmental disorder, when the insomnia is interfering with normal daily life and other therapies (behavioural and pharmacologic) have failed
Child:
Children 12 years and over:
The usual dose is 430-860 mg (15-30 ml of the 143mg/5ml strength). Higher doses should not exceed a maximum of 2 g chloral hydrate (70 ml of the 143mg/5ml strength) per dose.
Children (between 2 and 11 years):
30-50 mg/kg (1-1.75 ml/kg of the 143mg/5ml strength) of bodyweight. The dose should not exceed 1 g chloral hydrate (35 ml of the 143 mg/5ml strength) per dose.
Children under 2 years:
Chloral hydrate should not be used because the safety and efficacy of chloral hydrate in children aged under 2 years has not been established
Renal Dose
Renal Impairment
Contraindicated in moderate-severe renal impairment
Administration
Upon discontinuation withdraw gradually over 2 weeks if patient maintained on high doses for prolong periods of time; abrupt discontinuation may result in delirium. Dilute w/ water or other liquids (e.g. fruit juice, ginger ale).
Contra Indications
Hypersensitivity/idiosyncrasy to chloral derivatives.
Severe cardiac disease, acute porphyria, gastritis, oesophagitis, gastric/duodenal ulcer; obstructive sleep apnoea in childn. Marked hepatic or renal impairment. Lactation.
Precautions
Patient w/ resp insufficiency, sleep apnoea, depression, suicidal tendency, history of drug or alcohol abuse. Childn, elderly. Pregnancy.
Potential toxic dose <6 years old: 50 mg/kg
Use with caution in porphyria
Use caution in long term care patients, elderly, and neonates
Use not recommended for >2 weeks
Abrupt discontinuation may cause withdrawal symptoms
Pregnancy-Lactation
Pregnancy Category: C
Lactation: small amount secreted into breast milk
Interactions
Enhanced sedative effect w/ opiates, barbiturates, TCAs, antipsychotics, antihistamines, and other sedatives.
May cause hot flushes, sweating, and HTN w/ IV furosemide.
May cause delirium w/ anticholinergics or psychotropic.
May produce a transient increase in hypoprothrombinemic response to warfarin.
Contraindicated (2)
calcium/magnesium/potassium/sodium oxybates
sodium oxybate
Serious (14)
benzhydrocodone/acetaminophen
fentanyl
fentanyl intranasal
fentanyl transdermal
fentanyl transmucosal
hydrocodone
lemborexant
mefloquine
metoclopramide intranasal
olopatadine intranasal
selinexor
sufentanil SL
valerian
zuranolone
Adverse Effects
Side effects of Chloral Hydrate :
Significant: Gastric irritation (e.g. nausea, vomiting, diarrhoea), abdominal distention, flatulence, tolerance, dependence.
Nervous: Drowsiness, light-headedness, headache, paradoxical excitement, hallucination, nightmares, confusion, ataxia.
GI: Gastritis, unpleasant taste.
Genitourinary: Ketonuria, parenchymatous renal injury.
Dermatologic: Erythema multiforme, Stevens-Johnson syndrome.
Potentially Fatal: Delirium tremens.
Mechanism of Action
Chloral hydrate is a sedative and hypnotic w/ properties similar to paraldehyde and barbiturates. Its exact mechanism of action is unknown, however, it is believed that its CNS depressant effects are due to its active metabolite, trichloroethanol.
Note
Pediclor 143.3 mg Syrup manufactured by Beacon Pharmaceuticals Ltd.. Its generic name is Chloral Hydrate. Pediclor is availble in Bangladesh.
Farmaco BD drug index information on Pediclor Syrup is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.