Osiden Injection
Adenosine
6mg/2ml
Square Pharmaceuticals PLC.
| Pack size | 5's Pack |
|---|---|
| Dispensing mode | |
| Source | |
| Agent | |
| Retail Price | 40.00 AED |
Indications
Osiden Injection is used for:
Paroxysmal supraventricular tachycardia, Supraventricular tachycardia
Adult Dose
Intravenous
Differential diagnosis of supraventricular tachycardias
Adult: Initially, 3 mg by rapid IV inj into a central or large peripheral vein over 2 sec with cardiac monitoring; 6 mg may be given after 1-2 minutes if necessary, then 12 mg after a further 1-2 minutes. Avoid increments if high level AV block occurs at any particular dose.
Paroxysmal supraventricular tachycardia
Adult: Initially, 3 mg by rapid IV inj into a central or large peripheral vein over 2 sec with cardiac monitoring; 6 mg may be given after 1-2 minutes if necessary, then 12 mg after a further 1-2 minutes. Avoid increments if high level AV block occurs at any particular dose.
Myocardial imaging
Adult: 140 mcg/kg/minute by infusion for 6 minutes. Inject radionuclide 3 minute after infusion.
Child Dose
Intravenous
Differential diagnosis of supraventricular tachycardias
Child: Initially, 50-100 mcg/kg; if necessary, may increase dose by 50-100 mcg/kg increments at 1-2 minute intervals or until arrhythmia is controlled. Max dose: 300 mcg/kg.
Paroxysmal supraventricular tachycardia
Child: Initially, 50-100 mcg/kg; if necessary, may increase dose by 50-100 mcg/kg increments at 1-2 minute intervals or until arrhythmia is controlled. Max dose: 300 mcg/kg.
Myocardial imaging
Adult: 140 mcg/kg/minute by infusion for 6 minutes. Inject radionuclide 3 minute after infusion.
Renal Dose
Administration
IV Administration
Adenocard: given as a rapid injection (1-3 sec) by peripheral IV route directly into vein or into IV line close (proximal) to patient & is followed by rapid NS flush after each inj (20 mL for adults, 5 mL or more for peds)
Place pt in mild reverse Trendelenburg position before giving drug.
Contra Indications
Hypersensitivity
2nd or 3rd degree AV block (except those on pacemakers)
Sinus node disease, such as sick sinus syndrome or symptomatic bradycardia (except in patients with a functioning artificial pacemaker)
Adenosine: Contraindicated in bronchoconstrictive or bronchospastic lung disease (eg, asthma)
Precautions
Cardiac Arrest, Ventricular Arrhythmias, and Myocardial Infarction. Fatal cardiac events have occurred. Avoid use in patients with symptoms or signs of acute myocardial ischemia. Appropriate resuscitative measures should be available.
Sinoatrial (SA) and Atrioventricular (AV) Nodal Block. First-, second- or third-degree AV block, or sinus bradycardia can occur. Discontinue Adenosine if the patient develops persistent or symptomatic high-grade.
AV block
Bronchoconstriction. Can induce dyspnea, bronchoconstriction, and respiratory compromise, especially in patients with obstructive pulmonary disease. Discontinue Adenosine if the patient develops severe respiratory difficulties.
Hypotension. Significant hypotension can occur. Discontinue Adenosine if the patient develops persistent or symptomatic hypotension.
Cerebrovascular Accidents. Hemorrhagic and ischemic cerebrovascular accidents have occurred.
Seizures. New onset or recurrence of convulsive seizures have occurred. The use of methylxanthines (e.g., caffeine, aminophylline and theophylline) is
not recommended in patients who experience a seizure in association with Adenoscan
Hypersensitivity. Dyspnea, throat tightness, flushing, erythema, rash, and chest discomfort have occurred. Have personnel and resuscitative equipment immediately available.
Atrial Fibrillation. Reported in patients with or without a history of atrial fibrillation.
Hypertension. Clinically significant increases in systolic and diastolic pressure have been observed.
Monitoring Parameters
Monitor ECG and have resuscitation facilities available.
Pregnancy-Lactation
Pregnancy Category: C
Lactation: Potential for serious adverse reactions in nursing infants; decision to interrupt nursing after administration of adenosine or not should take into account importance of drug to mother
Interactions
Adenosine effects antagonised by methylxanthines like caffeine, theophylline, etc. Concomitant carbamazepine may increase the risk of heart block.
Contraindicated (0)
Serious - Use Alternative (1)
ponesimod
Potentially Fatal: Adenosine effects are potentiated by dipyridamole.
Adverse Effects
Side effects of Adenosine :
>10%
Flushing (18%),Dyspnea (12%)
1-10%
Chest pain (7%),HA (2%),Lightheadedness (2%),Dizziness (1%),Tingling in arms (1%),Numbness (1%),Nausea (3%)
<1%
Hypotension,Palpitations,Apprehension,Head pressure,Chest pain,Hyperventilation,Blurred vision,Burning sensation,Heaviness in arms, neck & back pain,Metallic taste,Tightness in throat,Pressure in groin,Sweating
Mechanism of Action
Adenosine acts rapidly to slow down conduction through the AV node via the A1 receptors. It also mediates peripheral and coronary vasodilatation by stimulating the A2 receptors. Extremely short plasma half-life (<10 sec) permits dosage titration during IV use every 1-2 min and causes no concern of cumulative effect through repeated dosing.
Note
Osiden 6mg/2ml Injection manufactured by Square Pharmaceuticals PLC.. Its generic name is Adenosine. Osiden is availble in Bangladesh.
Farmaco BD drug index information on Osiden Injection is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.