Orofit Solution
Benzydamine + Chlorhexidine gluconate mouth prep
(1.5mg+1.2mg)/ml
General Pharmaceuticals Ltd.
| Pack size | 120 ml |
|---|---|
| Dispensing mode | |
| Source | |
| Agent | |
| Retail Price | 150.00 AED |
Indications
Orofit Solution is used for:
Temporary relief of painful mouth & throat conditions including, tonsillitis, sore throat, radiation mucositis, aphthous ulcers, post-orosurgical & periodontal procedures.
Reduces plaque & gingivitis development during the treatment period
Adult Dose
Adult
Mouthwash
15 mL gargled for at least 30 sec at 1½ to 3 hourly intervals.
Rinse for oral lesion 15 mL held in mouth & swirled around for at least 30 sec w/ repeat use every 1½-3 hr throughout the day.
Child Dose
Children
Mouthwash
5-15 mL as gargle or oral rinse.
Uninterrupted treatment: Not to exceed 7 days.
Renal Dose
With Impaired Renal Function: Since absorbed benzydamine and its metabolites are excreted in the urine, the possibility of systemic effects should be considered in patients with severe renal impairment.
Administration
Contra Indications
Hypersensitivity.
Precautions
Hypersensitivity to chlorhexidine.
Discontinue use if any signs or symptoms of suspected hypersensitivity reaction develop.
Appropriate antibacterial therapy should be used in case bacterial infection occurs.
Prolonged use.
Severe hepatic or renal impairment.
Pregnancy.
Not recommended in children <6 yr.
Pregnancy-Lactation
Studies in animals are inadequate or may be lacking, but available data show no evidence of an increased occurrence of foetal damage.
The safety benzydamine hydrochloride has not been established in pregnant patients.
Risk to benefit ratio should be established if Benzydamine + Chlorhexidine gluconate is to be used in these patients.
Interactions
Adverse Effects
Side effects of Benzydamine + Chlorhexidine gluconate mouth prep :
Local Adverse Reactions:
The most commonly reported reaction is oral numbness (2.6%). Occasional burning or stinging sensation may occur and has been reported in 1.4% of treated cases. Other local adverse effects were less common and included dryness or thirst (0.2%), tingling (0.2%), warm feeling in mouth and altered taste (0.1%).
Systemic Adverse Reactions:
These were very uncommon and never of a serious nature. They consisted mainly of nausea, vomiting, retching, gastrointestinal disorders (0.4%), dizziness (0.1%), headache and drowsiness (0.1%). Hypersensitivity reactions occur very rarely but may be associated with pruritus, rash, urticaria, photodermatitis and occasionally laryngospasm or bronchospasm.
The most common side effects associated with chlorhexidine gluconate oral rinses are an increase in staining of teeth and other oral surfaces, an increase in calculus formation and an alteration in taste perception. Chlorhexidine tooth staining is harmless and can be minimized by thorough brushing of teeth before administration. No serious systemic adverse reactions associated with its use have been observed in clinical testing.
Immune System Disorders: Frequency not known: Hypersensitivity including anaphylactic shock.
Mechanism of Action
Benzydamine belongs to a family of medicines known as non-steroidal anti-inflammatory drugs (NSAIDs). They work to reduce pain and inflammation in the body by reducing the
production of hormone-like substances that promote the inflammatory response.
Benzydamine does not treat the underlying cause of the inflammation, however, and should not be used for extended periods of time without medical advice. Benzydamine also
possesses local anaesthetic activity to further enhance pain relief.
Chlorhexidine is an antiseptic agent that kills or prevents the growth of a wide range of bacteria that may be involved in causing pain and inflammation in conditions of the mouth
and throat. Chlorhexidine also helps to treat and prevent gingivitis and reduces the accumulation of dental plaque.
Note
Orofit (1.5mg+1.2mg)/ml Solution manufactured by General Pharmaceuticals Ltd.. Its generic name is Benzydamine + Chlorhexidine gluconate mouth prep. Orofit is availble in Bangladesh.
Farmaco BD drug index information on Orofit Solution is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.