Optibet 0.25% Eye Drops
Betaxolol 0.25% Eye prep
250 mg/100 ml
Jayson Pharmaceuticals Ltd.
| Pack size | 5 ml drop |
|---|---|
| Dispensing mode | |
| Source | |
| Agent | |
| Retail Price | 151.00 AED |
Indications
Optibet 0.25% Eye Drops is used for:
Glaucoma, Ocular hypertension
Adult Dose
Ophthalmic
Open-angle glaucoma
Adult: Instil 1-2 drops of 0.25% solution bid.
Ocular hypertension
Adult: Instil 1-2 drops of 0.25% solution bid.
Child Dose
Ophthalmic
Open-angle glaucoma
Child: Instil 1 drop of 0.25% solution bid.
Ocular hypertension
Child: Instil 1 drop of 0.25% solution bid.
Renal Dose
Administration
Contra Indications
Hypersensitivity. Sinus bradycardia, cardiogenic shock, overt cardiac failure. Pregnancy .
Precautions
General
Topically applied beta-adrenergic blocking agents may be absorbed systemically. The same types of cardiovascular and pulmonary and other adverse reactions found with systemic
administration of these agents may occur with topical administration. For example, severe respiratory reactions, including death due to exacerbation of bronchospasm in patients with
asthma, and rarely death in association with cardiac failure, have been reported with ophthalmic application of beta- adrenergic blocking agents.
Cardiovascular
While ophthalmic betaxolol hydrochloride has been shown to have a minor effect on heart rate and blood pressure in clinical studies, caution should be used in treating patients with a
history of cardiac failure or heart block. When beginning therapy with betaxolol patients with a history of severe cardiac disease should be monitored closely for signs of cardiac failure.
Treatment with ophthalmic betaxolol hydrochloride should be discontinued at the first sign of cardiac failure.
Because of potential effects of beta-blockers on blood pressure and pulse (e.g. hypotension, bradycardia), use with caution in patients with cerebrovascular insufficiency, untreated
phaeochromocytoma or metabolic acidosis, since beta-adrenergic blocking agents can adversely affect such diseases.
Pregnancy-Lactation
Pregnancy Category: C
Lactation: Excretion in milk unknown; use with caution
Interactions
Increased risk of bradycardia w/ digitalis glycosides. May cause mydriasis w/ epinephrine. Potential additive effect w/ oral Ca channel blockers, ?-adrenergic blockers, antiarrhythmics (including amiodarone), parasympathomimetics, guanethidine. Increased risk of myocardial depression and hypotension w/ peripheral muscle relaxants (e.g. tubocurarine).
Adverse Effects
Side effects of Betaxolol 0.25% Eye prep :
>10%
Ocular effects
Short term discomfort (<25%)
Frequency Not Defined
Ocular
Blurred vision,Corneal punctate keratitis,Itching and/or foreign body sensation erythema,Inflammation,Ocular pain and/or discharge,Ocular drynes,Photophobia
Systemic
Bradycardia, congestive heart failure, heart block,Depression, dizziness, headache, insomnia, lethargy, vertigo,Hair loss, hives, toxic epidermal necrolysis
Glossitis,Bronchospasm, dyspnea,Increase in signs and symptoms of myasthenia gravis
Mechanism of Action
Betaxolol is a cardioselective Beta-blocker which has greater affinity for ?1-receptors and has little or no effect on ?2-receptors. It lacks intrinsic sympathomimetic but has little membrane-stabilising activity. It also causes the reduction of intraocular pressure by decreasing the production of aqueous humour.
Note
Optibet 0.25% 250 mg/100 ml Eye Drops manufactured by Jayson Pharmaceuticals Ltd.. Its generic name is Betaxolol 0.25% Eye prep. Optibet 0.25% is availble in Bangladesh.
Farmaco BD drug index information on Optibet 0.25% Eye Drops is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.