Nutridex 50 Injection

Dextrose 50%

50%

Beximco Pharmaceuticals Ltd.

Pack size	100 ml bot
Dispensing mode
Source
Agent
Retail Price

Indications

Nutridex 50 Injection is used for: Parenteral Nutrition and Hydration, Hypoglycemia, Hyperkalaemia

Adult Dose

Intravenous Hypoglycaemia Adult: 10-25 g (20-50 ml of 50% solution). Doses may be repeated in severe cases. Hyperkalaemia Adult: 25-50 g combined with 10 units of regular insulin, administered over 30-60 minutes; may repeat if necessary. Alternatively, 25 g combined with 5-10 units of regular insulin infused over 5 minutes; may repeat if necessary.

Child Dose

Intravenous Hypoglycaemia Child: <6 mth: 0.25-0.5 g/kg/dose; >6 mth: 0.5-1 g/kg/dose. Doses may be repeated in severe cases. Max: 25 g/dose. Hyperkalaemia Child: and infants: 0.5-1 g/kg (using 50% solution) combined with regular insulin (1 unit for every 4-5 g dextrose given); infuse over 2 hr, may repeat if necessary.

Renal Dose

Administration

IV Administration Hypertonic dextrose solutions are preferably administered via an IV catheter placed into a large central vein If hypertonic (10%) dextrose solutions are administered peripherally, use a large arm vein, if possible, alternate injection site daily Except in the emergency treatment of severe hypoglycemia, higher concentrations of dextrose injections (e.g., 20% and higher) should be administered via central veins and only after appropriate dilution When used for the emergency treatment of hypoglycemia, hypertonic dextrose injections may be administered slowly via a peripheral vein Include final filter to administration protocol and visually inspect container

Contra Indications

The infusion of hypertonic dextrose injections is contraindicated in patients having intracranial or intraspinal hemorrhage, in patients who are severely dehydrated, in patients who are anuric, and in patients in hepatic coma. Solutions containing dextrose may be contraindicated in patients with known allergy to corn or corn products.

Precautions

Care should be taken to avoid circulatory overload, particularly in patients with cardiac insufficiency. Caution must be exercised in the administration of these injections to patients receiving corticosteroids or corticotropin. These injections should be used with caution in patients with overt or subclinical diabetes mellitus. Overt or known subclinical DM. Patients with carbohydrate intolerance. IV admin of dextrose may result in hypokalaemia, hypophosphataemia and hypomagnesemia. Prolonged infusion of isotonic dextrose solutions may cause water intoxication. Production of insulin may be adversely affected by prolonged parenteral nutrition with dextrose solutions. Rapid admin of hypertonic dextrose solutions may result in hyperglycaemia and hyperosmolar syndrome. Hypertonic solutions (>10%) may cause thrombosis when infused through peripheral veins; best to infuse through a central venous catheter. Increased serum osmolality and possible intracerebral hemorrhage may occur from rapid or excessive dextrose administration. Parenteral nutrition associated with liver disease; increased risk in patients who receive parenteral nutrition for extended periods of time, especially preterm infants. Caution when used in very low birth weight infants. Abrupt withdrawal may lead to rebound hypoglycaemia. Risk of thrombosis when hypertonic (>10%) solutions are administered through peripheral veins. Caution when used parenterally in pregnant women. Monitoring Parameters Monitor for signs of mental confusion or loss of consciousness. Monitor blood and urinary glucose regularly. Monitor changes in fluid balance, electrolyte concentrations, and acid-base balance during prolonged use. Monitor glucose levels and for possible hyperglycemia when treating pediatric patients. Monitor blood glucose and administer insulin as needed.

Pregnancy-Lactation

Pregnancy Category: C Maternal and fetal hyperglycemia may occur during labor and delivery; monitor Lactation: Excretion in milk unknown; use with caution

Interactions

Adverse Effects

Side effects of Dextrose 50% : Frequency Not Defined Hyperosmolarity Edema Venous thrombosis Tachypnea Fever Hypermolar syndrome Hypervolemia Phlebitis Diarrhea Polydipsia Pulmonary edema Cerebral hemorrhage Mental confusion, unconsciousness Cerebral ischemia Hypophosphatemia Hypomagnesemia Hyperglycemia Injection site extravasation Tissue necrosis

Mechanism of Action

Dextrose is a monosaccharide that is used as a source of calories and water for hydration. It helps to reduce loss of body protein and nitrogen. It also promotes glycogen deposition in the liver. When used with insulin, it stimulates the uptake of potassium by cells, especially in muscle tissue, thus lowering serum potassium levels.

Note

Nutridex 50 50% Injection manufactured by Beximco Pharmaceuticals Ltd.. Its generic name is Dextrose 50%. Nutridex 50 is availble in Bangladesh. Farmaco BD drug index information on Nutridex 50 Injection is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.