Nispore Eye Drops
Fluconazole 0.3% Eye prep
Incepta Pharmaceuticals Ltd.
| Pack size | 5 ml drop |
|---|---|
| Dispensing mode | |
| Source | |
| Agent | |
| Retail Price | 80 AED |
Indications
Nispore Eye Drops is used for:
Fungal corneal ulcers, Fungal keratitis, Fungal eye infections
Adult Dose
Adult: 1 - 2 drops to be instilled into the affected eye 5 times daily.
Child Dose
Renal Dose
Administration
Contra Indications
The drug is contraindicated in patients with hypersensitivity to azoles.
Precautions
Use of fluconazole may result in overgrowth of non-susceptible strains of candida other than C. albicans.
Pregnancy-Lactation
Interactions
May increase plasma concentrations of oral hypoglycaemics (e.g. tolbutamide, glyburide, glipizide), phenytoin, theophylline, tofacitinib, rifabutin. May increase prothrombin time w/ anticoagulants. May cause significant increase in ciclosporin levels in renal transplant patients w/ or w/o renal impairment. Rifampicin reduces fluconazole levels. May increase risk of nephrotoxicity w/ tacrolimus. May increase the effect of short-acting benzodiazepines (e.g. midazolam).
Potentially Fatal: Increased risk of cardiac arrhythmias or QT prolongation w/ terfenadine, cisapride, astemizole, pimozide, quinidine, halofantrine and erythromycin.
Adverse Effects
Side effects of Fluconazole 0.3% Eye prep :
This drug is generally well tolerated. Eosinophillia has been reported in some patients.
Mechanism of Action
Fluconazole decreases ergosterol synthesis by interfering w/ cytochrome P450 activity, thus inhibiting cell membrane formation of susceptible fungi including B. dermatitidis, Candida spp., C. immitis, C. neoformans, Epidermophyton spp., H. capsulatum, Micosporum spp., Trichophyton spp.
Note
Nispore Eye Drops manufactured by Incepta Pharmaceuticals Ltd.. Its generic name is Fluconazole 0.3% Eye prep. Nispore is availble in Bangladesh.
Farmaco BD drug index information on Nispore Eye Drops is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.