Neorex Capsule
Cephalexin
500mg
Eskayef Pharmaceuticals Ltd.
| Pack size | 50's pack |
|---|---|
| Dispensing mode | |
| Source | |
| Agent | |
| Retail Price | 12.50 AED |
Available as:
Indications
Neorex Capsule is used for:
Respiratory tract infections, Urinary tract infections, Bone and Joint Infections, Genitourinary tract infections, Pneumonia, Otitis media, Bacterial endocarditis, Streptococcal pharyngitis, Cellulitis, Acute prostatitis
Adult Dose
Oral
Bone and joint infections; Respiratory tract infections, Genitourinary Tract Infections, Otitis Media
Adults
1 to 4 g/day in divided doses.
Usual dose is 250 mg every 6 hours. But a dose of 500 mg every 12 hours may be administered
Streptococcal pharyngitis, skin and skin structure infections, uncomplicated cystitis, cellulitis and mastitis
500 mg every 12 hours.
Duration of therapy ranges from 7 to 14 days depending on the infection type and severity.
Child Dose
Children
> 15 years
Usual dose is 250 mg every 6 hours. But a dose of 500 mg every 12 hours may be administered
Children (over 1 year of age)
Otitis media: 75 to 100 mg/kg in equally divided doses every 6 hours
All other indications: 25 to 50 mg/kg given in equally divided doses
In severe infections: 50 to 100 mg/kg may be administered in equally divided doses
Duration of therapy ranges from 7 to 14 days depending on the infection type and severity.
Renal Dose
Renal impairment:
CrCl (ml/min)
40-50 Max: 3 g daily.
10-40 Max: 1.5 g daily.
<10 Max: 750 mg daily.
Administration
May be taken with or without food. May be taken w/ meals to reduce GI discomfort.
Contra Indications
Hypersensitivity to cephalosporins.
Precautions
Serious hypersensitivity (anaphylactic) reactions: Prior to use, inquire regarding history of hypersensitivity to beta-lactam antibacterial drugs. Discontinue the drug if signs or symptoms of an allergic reaction occur and institute supportive measures.
Clostridium difficile-associated diarrhea (CDAD): Evaluate if diarrhea occurs.
Direct Coomb’s Test Seroconversion: If anemia develops during or after cephalexin therapy, evaluate for drug-induced hemolytic anemia.
Seizure Potential: Use lower dose in patients with renal impairment.
Pregnancy-Lactation
Pregnancy
There are no adequate and well-controlled studies
Available data from published epidemiologic studies and pharmacovigilance case reports over several decades with cephalosporin use, use in pregnant women have not established drug-associated risks of major birth defects, miscarriage, or adverse maternal or fetal outcomes
Animal data
Animal reproduction studies with mice and rats using oral doses of cephalexin that are 0.6- and 1.2-times the maximum recommended human dose (MRHD) based on body surface area during organogenesis revealed no evidence of harm to the fetus; estimated background risk of major birth defects and miscarriage for indicated population is unknown
Lactation
Data from a published clinical lactation study reports that cephalexin is present in human milk; relative infant dose (RID) is considered to be <1% of maternal weight adjusted dose; there are no data on effects of cephalexin on breastfed child or on milk production
Development of health benefits of breastfeeding should be considered along with mother’s clinical need for therapy and any potential adverse effects on breastfed child from therapy or from underlying maternal condition
Interactions
Concurrent use w/ metfromin may result to fatal lactic acidosis.
May enhance the anticoagulant effect of vit K antagonists (e.g. warfarin).
Increased risk of nephrotoxicity w/ potent diuretics (e.g. ethacrynic acid, furosemide) and other potentially nephrotoxic antibiotics (e.g. aminoglycosides, polymyxin, colistin).
Prothrombin time may be prolonged when used concomitantly w/ oral anticoagulants.
May reduce the effects of OCs.
Hypokalaemia may result from concomitant use of cefalexin and cytotoxic drugs for leukaemia.
Uricosuric drugs (e.g. probenecid) may suppress renal excretion, resulting to increased plasma levels of cefalexin.
May diminish the therapeutic effect of Na picosulfate, BCG and typhoid vaccine.
May reduce serum level w/ multivitamins/minerals.
Contraindicated (0)
Serious (4)
BCG vaccine live
cholera vaccine
microbiota oral
typhoid vaccine live
Adverse Effects
Side effects of Cephalexin :
Frequency Not Defined
Abdominal pain
Agitation
Anemia
Angioedema
Confusion
Diarrhea
Dizziness
Dyspepsia
Elevated transaminases
Eosinophilia hemolytic
Epidermal necrolysis
Erythema multiform
Fatigue
Gastritis
Genital pruritus
Hallucinations
Headache
Hemolytic anemia
Hypersensitivity
Nephritis
Neutropenia
Pseudomembranous colitis
Thrombocytopenia
Transient hepatitis
Toxic epidermal necrolysis
Urticaria
Vaginal discharge
Vomiting
Potentially Fatal: Anaphylactic reactions; nephrotoxicity.
Mechanism of Action
Cefalexin binds to one or more of the penicillin-binding proteins (PBPs) which inhibits the final transpeptidation step of peptidoglycan synthesis in bacterial cell wall, thus inhibiting biosynthesis and arresting cell wall assembly resulting in bacterial cell death.
Note
Neorex 500mg Capsule manufactured by Eskayef Pharmaceuticals Ltd.. Its generic name is Cephalexin. Neorex is availble in Bangladesh.
Farmaco BD drug index information on Neorex Capsule is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.