Neopem Tablet
Faropenem sodium
150 mg
Beximco Pharmaceuticals Ltd.
| Pack size | 20's pack |
|---|---|
| Dispensing mode | |
| Source | |
| Agent | |
| Retail Price | 75.00 AED |
Available as:
Indications
Neopem Tablet is used for:
Upper and Lower Respiratory tract infections, Uncomplicated skin and skin structure infections, Urinary tract infections, Ear, nose and throat (ENT) infections
Adult Dose
Oral
Tablet
Urinary tract infections, Lower respiratory tract infections, ENT infections
200 mg t.i.d., can be increased to 300 mg t.i.d.
Upper respiratory tract infections, Skin and skin structure infections
150 mg t.i.d., can be increased to 200 mg t.i.d.
Child Dose
Renal Dose
Administration
It may be taken with or without food.
Contra Indications
History of hypersensitivity to faropenem and other penems, anaphylactic reaction to beta-lactams.
Precautions
Patients with a past history of hypersensitivity to penicillin, cephem or carbapenem drugs.
Patients with a family history of atopy.
Patients with renal impairment. The dosage should be reduced or the interval between doses should be increased.
Geriatric patients.
Patients with poor oral intake or poor general state (since there are cases that show symptoms of vitamin K deficiency, proper monitoring should be done).
Pregnancy-Lactation
Pregnancy: Safety regarding therapy during pregnancy has not been established. In pregnant women or expectant mothers, the medicine should be given only if the benefits of the treatment are greater than the risks involved.
Nursing Mother: Faropenem is excreted in human milk. Therefore, Faropenem should be given to nursing mothers only if the benefits outweigh the risks
Interactions
Imipenem and Cilastatin sodium combination: It has been reported that in animal studies (rat), the concentration of faropenem in the blood increases. It is due to the obstruction of metabolic fermentation by cilastatin.
Furosemide: It has been reported in animal studies (dog), that the kidney toxicity of faropenem increases.
Sodium valproate: It has been reported that due to joint usage with carbapenem drugs (meropenem, panipenem and imipenem-cilastatin sodium) the concentration of valproic acid
in the blood reduces, and there is a recurrence of epileptic fits.
Adverse Effects
Side effects of Faropenem sodium :
Faropenem is generally well tolerated. The most frequently reported adverse reactions are diarrhea, abdominal pain, loose bowel movements, nausea, vomiting and rash.
Mechanism of Action
Faropenem is a penem antimicrobial and has bactericidal activity against a variety of gm-ve, gm+ve and anaerobic bacteria.
Like other beta-lactam antibiotics, faropenem acts by inhibiting the synthesis of bacterial cell walls. It inhibits cross-linkage between the linear peptidoglycan polymer chains that make up a major component of the cell wall of Gram-positive bacteria. It does this by binding to and competitively inhibiting the transpeptidase enzyme used by bacteria to cross-link the peptide (D-alanyl-alanine) used in peptidogylcan synthesis.
Note
Neopem 150 mg Tablet manufactured by Beximco Pharmaceuticals Ltd.. Its generic name is Faropenem sodium. Neopem is availble in Bangladesh.
Farmaco BD drug index information on Neopem Tablet is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.