Navafil 50 Tablet
Avanafil
50mg
Delta Pharma Limited
| Pack size | 8's Pack |
|---|---|
| Dispensing mode | |
| Source | |
| Agent | |
| Retail Price | 50.00 AED |
Available as:
Indications
Navafil 50 Tablet is used for:
Erectile Dysfunction
Adult Dose
Erectile Dysfunction
100 mg PO initially as early as 15 min before sexual activity; not to exceed 1 dose/day
Based on individual efficacy and tolerability, the dose may be increased to 200 mg taken as early as ~15 minutes before sexual activity, or decreased to 50 mg taken ~30 minutes before sexual activity
Use the lowest effective dose
Child Dose
Renal Dose
Renal Impairment
Mild-to-moderate (CrCl ?30 mL/min): Dose adjustment not necessary
Severe impairment (CrCl 15-29 mL/min): Safety and efficacy not established; do not use
Administration
May take with or without food
Contra Indications
Hypersensitivity
Soluble guanylate cyclase (sGC) stimulators (eg, riociguat or vericiguat); concomitant use can cause hypotension
Coadministration with nitrates
Coadministration with nitrates (either regularly and/or intermittently) and nitric oxide donors
Consistent with the effects of PDE5 inhibition on the nitric oxide/cyclic guanosine monophosphate pathway, PDE5 inhibitors may potentiate the hypotensive effects of nitrates
A suitable time interval following PDE5 dosing for the safe administration of nitrates or nitric oxide donors has not been determined
Precautions
Patients should not use Avanafil if sexual activity is inadvisable due to cardiovascular status or any other reason
Use of Avanafil with alpha-blockers, other antihypertensives, or substantial amounts of alcohol (greater than 3 units) may lead to hypotension
Patients should seek emergency treatment if an erection lasts greater than 4 hours
Patients should stop Avanafil and seek medical care if a sudden loss of vision occurs in one or both eyes, which could be a sign of Non
Arteritic Ischemic Optic Neuropathy (NAION). Avanafil should be used with caution, and only when the anticipated benefits outweigh the risks, in patients with a history of NAION. Patients with a “crowded” optic disc may also be at an increased risk of NAION
Patients should stop taking Avanafil and seek prompt medical attention in the event of a sudden decrease or loss of hearing
Monitoring Parameters
Monitor patients with left ventricular outflow obstruction (eg, aortic stenosis, idiopathic hypertrophic subaortic stenosis)
Pregnancy-Lactation
Pregnancy Category: C
Lactation: Safety and efficacy not established
Interactions
Avanafil can potentiate the hypotensive effect of nitrates, alpha-blockers, antihypertensives, and alcohol
CYP3A4 inhibitors (e.g., ketoconazole, ritonavir, erythromycin) increase Avanafil exposure
Contraindicated (13)
chloramphenicol
isosorbide dinitrate
isosorbide mononitrate
itraconazole
nitroglycerin IV
nitroglycerin PO
nitroglycerin rectal
nitroglycerin sublingual
nitroglycerin topical
nitroglycerin transdermal
nitroglycerin translingual
riociguat
vericiguat
Serious - Use Alternative (38)
amyl nitrite
apalutamide
atazanavir
ceritinib
clarithromycin
cobicistat
conivaptan
darunavir
enzalutamide
eslicarbazepine acetate
fexinidazole
fosamprenavir
idelalisib
imatinib
indinavir
isoniazid
ivosidenib
ketoconazole
levoketoconazole
lonafarnib
lopinavir
lorlatinib
mifepristone
mitotane
nefazodone
nelfinavir
nicardipine
nirmatrelvir/ritonavir
nitroprusside sodium
posaconazole
ritonavir
saquinavir
tipranavir
tovorafenib
tucatinib
vardenafil
voriconazole
voxelotor
Adverse Effects
Side effects of Avanafil :
>2%
Headache (5.6%)
Flushing (3.5%)
Nasal congestion (2.1%)
Nasopharyngitis (3.4%)
Back pain (2.5%)
Upper respiratory infection (<2%)
Bronchitis (<2%)
Influenza (<2%)
Sinusitis (<2%)
Sinus congestion (<2%)
Hypertension (<2%)
Dyspepsia (<2%)
Nausea (<2%)
Constipation (<2%)
Rash (<2%)
<1%
Peripheral edema
Fatigue
Angina
Deep vein thrombosis
Palpitations
Gastritis
Gastroesophageal reflux disease
Hypoglycemia
Hyperglycemia
Oropharyngeal pain
Stomach discomfort
Vomiting
Depression
Insomnia
Cough
Dyspnea exertional
Epistaxis
Wheezing
Pruritus
Urinary tract infection
Pollakiuria
Nephrolithiasis
Hematuria
Increased erection
Balanitis
Mechanism of Action
Sexual stimulation causes nitric oxide to be released in the corpus cavernosum; nitric oxide activates the enzyme guanylate cyclase, which in turn increases cGMP levels; increase in cGMP levels causes smooth muscle relaxation.
Phosphodiesterase type 5 inhibitors enhance the effects of nitric oxide in smooth muscle relaxation of the corpus cavernosum by inhibiting the degradation of cGMP.
Note
Navafil 50 50mg Tablet manufactured by Delta Pharma Limited. Its generic name is Avanafil. Navafil 50 is availble in Bangladesh.
Farmaco BD drug index information on Navafil 50 Tablet is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.