Mydrate Eye Drops

Cyclopentolate Hydrochloride Eye prep

10 mg/ml

Beximco Pharmaceuticals Ltd.

Pack size	5 ml drop
Dispensing mode
Source
Agent
Retail Price	120.00 AED

Indications

Mydrate Eye Drops is used for: Pediatric eye examinations, Mydriasis, Cycloplegia, Uveitis, Iritis

Adult Dose

Ophthalmic Mydriasis and cycloplegia for diagnosis Adult: Instill 1-2 drops into the affected eye/s repeated after 5-15 minutes.

Child Dose

Ophthalmic Mydriasis and cycloplegia for diagnosis Child 3 months–11 years: Apply 1 drop, 30–60 minutes before examination, using 1% eye drops repeated after 5-15 minutes. Infants <3 mth: Not recommended. Child 12–17 years: Apply 1 drop, 30–60 minutes before examination, using 0.5% eye drops

Renal Dose

Administration

Contra Indications

Children under 3 months of age, Glaucoma, or people with a tendency to glaucoma because of a shallow anterior chamber, Conditions where the gut is not functioning properly, resulting in an obstruction in the bowel (paralytic ileus), Children with organic brain syndromes, including congenital or neuro-developmental abnormalities such as epilepsy. This medicine should not be used if history of allergies to one or any of its ingredients.

Precautions

The elderly may be predisposed to increased intraocular pressure Mydriatics may produce transient elevation of intraocular pressure; patients with untreated narrow-angle glaucoma or anatomically narrow angles may be susceptible to angle-closure following administration Dropper tip is not to touch any surface, as this may contaminate the solution A transient burning sensation may occur upon instillation Patients should be advised not to drive or engage in other hazardous activities while pupils are dilated Patients may experience sensitivity to light and should protect eyes in bright illumination during dilation Parents should be warned not to get this preparation in their child's mouth and to wash their own hands and the child's hands following administration Feeding intolerance may follow ophthalmic use of this product in infants; it is recommended that feeding be withheld for 4 hours after examination CNS effects May cause central nervous system (CNS) disturbances, especially in younger age groups but may occur at any age, especially with stronger solutions Infants are especially prone to CNS and cardiopulmonary side effects

Pregnancy-Lactation

Pregnancy Animal reproduction studies have not been conducted; not known whether cyclopentolate can cause fetal harm when administered to a pregnant woman or can affect reproduction capacity; administer to a pregnant woman only if clearly needed Lactation Not known whether this drug is excreted in human milk; because many drugs are excreted in human milk, exercise caution when drug is administered to a nursing woman

Interactions

Plasma concentration may be increased with the use of cimetidine, diltiazem, disulfiram, methylphenidate, ritonavir, and verapamil. Side-effects are increased by adrenaline, amiodarone, general anesthetics, SSRIs, antihistamines, antimuscarinics, antipsychotics, anxiolytics and hypnotics, clozapine, disopyramide, diuretics, flecainide, MAOIs, moclobemide, moxifloxacin, nefopam, nicorandil, noradrenaline, phenothiazine, pimozide, procainamide, propafenone, quinidine, selegiline, sibutramine, sotalol, terfenadine, thioridazine, and tramadol. Effects of adrenergic neurone blockers, clonidine, barbiturates, nitrates, and primidone are reduced while effects of baclofen, opioid analgesics, and thyroid hormones are enhanced with concomitant use of cyclobenzaprine. Carbamazepine and rifampicin may increase metabolism of cyclobenzaprine. Effects may be antagonized by oestrogens. Avoid use with brimonidine, entacapone, artemether with lumefantrine, or sibutramine. CNS effects may be enhanced by other CNS depressants.

Adverse Effects

Side effects of Cyclopentolate Hydrochloride Eye prep : Frequency Not Defined Blurred vision Burning sensation in eye Light intolerance Tachycardia Conjunctivitis Raised intraocular pressure Hyperreactive response in Down's syndrome children (atropine) Drowsiness

Mechanism of Action

Cyclopentolate is an anticholinergic. It produces dilatation of the pupil and paralysis of accommodation. Has a shorter duration of action than atropine.

Note

Mydrate 10 mg/ml Eye Drops manufactured by Beximco Pharmaceuticals Ltd.. Its generic name is Cyclopentolate Hydrochloride Eye prep. Mydrate is availble in Bangladesh. Farmaco BD drug index information on Mydrate Eye Drops is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.