Monabacin Ointment
Bacitracin Zinc + Neomycin Sulphate Topical
500IU + 5mg/gm
Amico Laboratories Ltd.
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| Retail Price | 16.65 AED |
Indications
Monabacin Ointment is used for:
Bacterial skin infections
Adult Dose
Adult: Topical: Cream: Apply 3 times/day.
Powder: Apply 2-4 times/day.
Child Dose
Topical: Cream: Apply 3 times/day.
Powder: Apply 2-4 times/day.
Renal Dose
Administration
Contra Indications
Hypersensitivity to aminoglycosides. Pre-existing nerve deafness. Neonates and infants <2 yr.
Precautions
Avoid application in large quantities and prolonged use. Pregnancy and lactation. Liver and renal impairment.
Pregnancy-Lactation
The safe use of this preparation during pregnancy & lactation has not been established. Therefore it should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.
Interactions
Bacitracin Zinc: Increased risk of nephrotoxicity when used with other nephrotoxic drugs. May enhance the action of neuromuscular-blocking agents.
Neomycin Sulphate: Additive nephrotoxic and neurotoxic effect w/ other aminoglycosides (e.g. paromomycin), bacitracin, cisplatin, vancomycin, amphotericin B, polymyxin B, colistin and viomycin. Enhanced toxicity w/ potent diuretics (e.g. ethacrynic acid, furosemide). May impair the absorption of other drugs (e.g. phenoxymethylpenicillin, digoxin, methotrexate and some vit). May reduce the efficacy of OCs. May enhance the effect of acarbose. May enhance the effect of non-depolarising muscle relaxants. May antagonise the parasympathomimetic effect of neostigmine and pyridostigmine. May increase the risk of hypocalcaemia in patients receiving bisphosphonates. May alter INR when given w/ anticoagulants. May inactivate oral typhoid vaccine.
Adverse Effects
Side effects of Bacitracin Zinc + Neomycin Sulphate Topical :
>10%
Allergic contact dermatitis (60%)
Mechanism of Action
Neomycin, an aminoglyoside with antimicrobial spectrum similar to gentamicin, binds to the 30S subunits of the bacterial ribosome, inhibiting protein synthesis and thereby disrupting DNA synthesis. It is active against many gram-negative aerobes and against some strains of staphylococci. Bacitracin, on the other hand, inhibits bacterial cell wall synthesis and is active against many gram-positive bacteria (e.g. staphylococci, streptococci, corynebacteria and clostridia) and some gram-negative species (e.g. Neisseria and Haemophilus influenzae). They are often found in combinations in topical preparations as broad spectrum antibacterial agents.
Note
Monabacin 500IU + 5mg/gm Ointment manufactured by Amico Laboratories Ltd.. Its generic name is Bacitracin Zinc + Neomycin Sulphate Topical. Monabacin is availble in Bangladesh.
Farmaco BD drug index information on Monabacin Ointment is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.