Momento PLUS Tablet
Desloratadine + Pseudoephedrine Sulphate
5mg + 240mg
Beximco Pharmaceuticals Ltd.
| Pack size | 100's Pack |
|---|---|
| Dispensing mode | |
| Source | |
| Agent | |
| Retail Price |
Available as:
Indications
Momento PLUS Tablet is used for:
Allergic rhinitis, Itching, Sneezing, Watery eyes, Runny nose, Hives, Skin rash, Common cold, Nasal congestion
Adult Dose
Oral
Adults:
1 tablet (2.5 mg desloratadine/120 mg pseudoephedrine) 12 hourly.
1 tablet (5 mg desloratadine/240 mg pseudoephedrine) 24 hourly.
Child Dose
Oral
Child:
12 years or over: 1 tablet (2.5 mg desloratadine/120 mg pseudoephedrine) 12 hourly.
1 tablet (5 mg desloratadine/240 mg pseudoephedrine) 24 hourly.
Renal Dose
Renal Impairment
Not recommended
Administration
May be taken with or without food: Swallow whole, do not chew/break/crush.
Contra Indications
Hypersensitivity
Narrow-Angle Glaucoma
Urinary Retention
Patients receiving MAO Inhibitors or within 14 days of stopping such treatment
Severe hypertension or severe coronary artery disease
Precautions
Cardiovascular and central nervous system effects: Use with caution in patients with cardiovascular disorders.
Coexisting conditions: Use with caution in patients with increased intraocular pressure, prostatic hypertrophy, diabetes mellitus, or hyperthyroidism.
Pregnancy-Lactation
Pregnancy
The limited available data in pregnant women are not sufficient to inform a drug-associated risk for major birth defects and miscarriage; there are no adequate and well-controlled studies in pregnant women
The majority of studies examining use of pseudoephedrine in pregnancy did not find an association with increased risk of congenital anomalies; a few case-control studies conducted reported potential associations with isolated congenital disorders; however, methodological limitations of these studies made the interpretation of results unreliable
Reproductive potential
There are no data available on human infertility associated with desloratadine, pseudoephedrine, or combination; there are no animal fertility studies with combination or pseudoephedrine alone
Female: There were no clinically relevant effects of desloratadine on female fertility in rats
Male: A male specific decrease in fertility occurred at an oral desloratadine dose of ?12 mg/kg in rats (approximately 65 times the RHD); male fertility was unaffected at a desloratadine dose of 3 mg/kg (approximately 10 times the RHD)
Lactation
Desloratadine and pseudoephedrine both pass into breast milk; there are no sufficient data on effects of desloratadine on breastfed infant or effects of desloratadine on milk production
Pseudoephedrine has been reported to decrease milk production and to cause irritability in breastfed infants; the decision should be made whether to discontinue nursing or to discontinue drug, taking into account developmental and health benefits of breastfeeding, the nursing mother’s clinical need, and any potential adverse effects on breastfed infant from therapy or from underlying maternal condition
Interactions
Potential increase in plasma concentrations w/ drugs affecting hepatic microsomal enzymes (e.g. azithromycin, cimetidine, erythromycin, fluoxetine, ketoconazole).
Increased risk of hypertension and arrhythmias if given with cardiac glycosides, quinidine or TCAs.
Increased risk of vasoconstrictor effects if given with ergot alkaloids or oxytocin.
Co-administration with MAOIs may cause hypertensive crisis.
Anaesthetics e.g. cyclopropane, halothane and other halogenated anesthetics; antihypertensive agents.
Contraindicated (16)
dihydroergotamine
dihydroergotamine inhaled
dihydroergotamine intranasal
ergoloid mesylates
ergonovine
ergotamine
isocarboxazid
linezolid
methylergonovine
phenelzine
procarbazine
rasagiline
selegiline
selegiline transdermal
thalidomide
tranylcypromine
Adverse Effects
Side effects of Desloratadine + Pseudoephedrine Sulphate :
>10%
Desloratadine
Fever (12%),Irritability (12%),Headache (12%),Diarrhea (15-21%),Cough (11%),Upper respiratory tract infection (11-21%)
1-10%
Desloratadine
Pharyngitis (4.1%),Dry mouth (3%),Myalgia (2.1%),Emotional lability (3%),Erythema (3%),Macopapular rash (3%),Dizziness (4%),Fatigue (2.1%),Somnolence (2.1%)Urinary tract infection (4%),Dyspepsia (3%),Insomnia (5%),Dysmenorrhea (2.1%)
Frequency Not Defined
Pseudoephedrine
CNS (tremor, restlessness, etc),Insomnia,Arrhythmia,Hypotension,Tachycardia,Fatigue,Rash,Urticaria,Anorexia,Xerostomia,Dysuria,Polyuria,Nausea,Vomiting,Ischemic colitis
Mechanism of Action
Desloratadine is a long-acting, tricyclic, non-sedating, selective peripheral histamine H1-receptor antagonist which inhibits the release of pro-inflammatory mediators from human mast cells and basophils.
Pseudoephedrine is both an ?-and ?-adrenergic receptor agonist. It causes vasoconstriction via direct stimulation of ?-adrenergic receptors of the respiratory mucosa. It also directly stimulates ?-adrenergic receptors causing bronchial relaxation, increased heart rate and contractility.
Note
Momento PLUS 5mg + 240mg Tablet manufactured by Beximco Pharmaceuticals Ltd.. Its generic name is Desloratadine + Pseudoephedrine Sulphate. Momento PLUS is availble in Bangladesh.
Farmaco BD drug index information on Momento PLUS Tablet is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.