Mirogab Tablet
Mirogabalin
2.5 mg
Beacon Pharmaceuticals Ltd.
| Pack size | 30's pack |
|---|---|
| Dispensing mode | |
| Source | |
| Agent | |
| Retail Price | 12.00 AED |
Available as:
Indications
Mirogab Tablet is used for:
Peripheral neuropathic pain, Diabetic peripheral neuropathic pain, Postherpetic Neuralgia
Adult Dose
Oral
Tablet
In general, for adults, the initial dose of 5 mg of Mirogabalin is orally administered twice daily, then the dose can be gradually increased by 5 mg at intervals of 1 week or longer.
The dose may be adjusted according to the patient's age and symptoms in the range of 10 mg to 15 mg, and administered twice daily.
Child Dose
Renal Dose
Administration
Contra Indications
Mirogabalin is contraindicated in patients with known hypersensitivity to Mirogabalin or any of its components.
Patients with severe Hepatic & Renal impairment.
Precautions
Dose adjustment is needed in patients with renal dysfunction. Mirogabalin may cause dizziness or somnolence, the patient should avoid operating in potentially hazardous activities such as driving a car.
Elderly patients should be aware of falling and fractures.
Mirogabalin may cause blurred vision or double vision.
Mirogabalin may cause weight gain.
Pregnancy-Lactation
Pregnant women: For pregnant or potentially pregnant women, administer only if the therapeutic benefit outweighs the risks.
The presence in placental passage has been reported in animal studies.
Lactating women: Consider the therapeutic and breastfeeding benefits then consider continuing or discontinuing breastfeeding.
It has been reported in animal studies that it is transferred into milk.
Interactions
Mirogabalin does not inhibit or induce major human CYP molecular species and does not inhibit activities of drug transporters.
Co-administrated with OAT1, OAT3, OCT2, MATE1, MATE2-K or UGT inhibitor may increase mirogabalin exposure, so used with caution.
Co-administration of Mirogabalin with Cimetidine or Probenecid may raise the Mirogabalin plasma concentration.
Importantly, if Mirogabalin is taken with Lorazepam, the depressive effects on the CNS may be potentiated.
Adverse Effects
Side effects of Mirogabalin :
Somnolence, dizziness, edema, weight gain and headache.
Mechanism of Action
Mirogabalin has selective and potent binding affinities for α2δ-1 subunit of VGCCs (Voltage Gated Calcium Channel), which reduces calcium (Ca2+) influx and neurotransmission in DRG (Dorsal root ganglia), inhibiting neurotransmitter release in presynaptic neuron endings, thus gives analgesic effect.
Note
Mirogab 2.5 mg Tablet manufactured by Beacon Pharmaceuticals Ltd.. Its generic name is Mirogabalin. Mirogab is availble in Bangladesh.
Farmaco BD drug index information on Mirogab Tablet is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.