Microgest AQ S/C Injection
Progesterone inj
25mg/1.119 mL
Renata PLC.
| Pack size | 1 x 5’s ampoules |
|---|---|
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Indications
Microgest AQ S/C Injection is used for:
Assisted reproductive technology
Adult Dose
Subcutaneous
Assisted reproductive technology
Indicated for progesterone supplementation in women up to and including 34 years of age who are unable to use or tolerate vaginal preparations and undergoing In Vitro Fertilization (IVF) with or without Intracytoplasmic Sperm Injection (ICSI).
Adult:
In patients who require progesterone supplementation for luteal support who are unable to use or tolerate vaginal preparations:
Once daily SC injection of 25 mg from day of oocyte retrieval for up to 10 weeks of total duration, usually until 12 weeks of confirmed pregnancy.
Child Dose
Renal Dose
Administration
SC injection only.
Contra Indications
Hypersensitivity to progesterone, soybean lecithin, peanut, palm oil, or sesame seed/oil. Undiagnosed vaginal bleeding, known or suspected malignancy of the breast or genital organs, missed abortion or ectopic pregnancy, active or history of thrombophlebitis or thromboembolic disorders, porphyria. Severe hepatic impairment.
Precautions
Patient with diseases that may be exacerbated by fluid retention (e.g. cardiac impairment, asthma, migraine, epilepsy), diabetes, hypercholesterolaemia, hypertension, SLE, personal or family history of venous thromboembolism, history of depression. Patients undergoing surgery; obese, smokers, >35 years. Abrupt withdrawal. Renal and mild to moderate hepatic impairment. Pregnancy and lactation.
Pregnancy-Lactation
FDA pregnancy category B.
It is not recommended during pregnancy, labor or delivery and in mothers who are breastfeeding.
Interactions
Decreased bioavailability with CYP3A4 inducers (e.g. rifampicin, carbamazepine, phenobarbital, phenytoin, griseofulvin, spironolactone). Increased bioavailability with CYP3A4 inhibitors (e.g. ketoconazole, ritonavir). May inhibit ciclosporin metabolism leading to increase plasma ciclosporin concentrations and risk of toxicity. May diminish the therapeutic effect of antidiabetic agents. May diminish the therapeutic effect with other vaginal products (e.g. antifungal agents).
Adverse Effects
Side effects of Progesterone inj :
Significant: Increased risk of invasive breast cancer, endometriosis, transient dizziness and drowsiness, eosinophilic pneumonia (particularly in inj preparations containing sesame oil), fluid retention, retinal vascular thrombosis, increase risk of probable dementia (in women ≥65 years), toxic shock syndrome (vaginal preparations); increase risk of DVT, pulmonary embolism, stroke, MI; decrease glucose tolerance. Rarely, increase the risk of ovarian cancer.
Gastrointestinal disorders: Abdominal pain, bloating, nausea, vomiting, diarrhoea, constipation, cramps, abdominal distention.
General disorders and admin site conditions: Irritability, fatigue, pyrexia; injection site pain, irritation, swelling, redness, haematoma, or induration.
Hepatobiliary disorders: Cholestatic jaundice.
Metabolism and nutrition disorders: Weight changes, peripheral edema.
Musculoskeletal and connective tissue disorders: Musculoskeletal pain.
Nervous system disorders: Headache, nervousness.
Psychiatric disorders: Depression, anxiety, insomnia.
Renal and urinary disorders: Urinary problems.
Skin and subcutaneous tissue disorders: Rash, urticaria, melasma, alopecia; genital pruritus; acne vulgaris, hirsutism (inj).
Vascular disorders: Hot flush.
Mechanism of Action
Progesterone, a naturally occurring steroid that is secreted by the ovary, placenta, and adrenal gland that acts on the endometrium by converting the proliferative phase to the secretory phase. It promotes mammary gland development, blocks follicular maturation and ovulation, relaxes uterine smooth muscle, maintains pregnancy, and induces adequate endometrial maturity, thus promoting embryo implantation.
Note
Microgest AQ 25mg/1.119 mL S/C Injection manufactured by Renata PLC.. Its generic name is Progesterone inj. Microgest AQ is availble in Bangladesh.
Farmaco BD drug index information on Microgest AQ S/C Injection is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.