MarinCal-DX Tablet

Calcium (Coral Source) + Vitamin D3

600mg + 400IU

Incepta Pharmaceuticals Ltd.

Pack size	30's Pack
Dispensing mode
Source
Agent
Retail Price	16.00 AED

Available as:

500mg + 200IU - Tablet

Indications

MarinCal-DX Tablet is used for: Calcium and vitamin D deficiency, Calcium and vitamin D supplements, Osteoporosis, Osteomalacia, Tetany, Hypoparathyroidism

Adult Dose

Oral Adult 1-2 tablets daily, preferably one tablet each morning and evening.

Child Dose

Renal Dose

Administration

Should be taken with food.

Contra Indications

Hypercalcemia and hyperparathyroidism Hypercalciuria and nephrolithiasis Hypersensitivity to the component of this preparation Severe renal insufficiencies

Precautions

Patients with mild to moderate renal failure or mild hypercalciuria should be supervised carefully including periodic checks of plasma calcium levels and urinary calcium excretion. In patients with a history of renal stones, urinary calcium excretion should be measured to exclude hypercalciuria. With long-term treatment it is advisable to monitor serum and urinary calcium levels and kidney function, and reduce or stop treatment temporarily if urinary calcium exceeds 7.5 mmol/24 hours (300 mg/24 hours). Caution is required in patients receiving treatment for cardiovascular disease (thiazide diuretics and cardiac glycosides including digitalis). MONITORING PARAMETERS Monitor ECG and serum calcium levels.

Pregnancy-Lactation

This is safe to take during pregnancy at the recommended doses. However, during pregnancy, the daily dose should not exceed 1500 mg of calcium and 600 IU of vitamin D. Animal studies have shown toxic effects on reproduction at high doses of vitamin D. In pregnant women, all calcium or vitamin D overdoses must be avoided as prolonged hypercalcemia in pregnancy may lead to retardation of physical and mental development, supravalvular aortic stenosis and retinopathy in the child. There are no indications that Vitamin D3 at therapeutic doses is teratogenic in humans. Lactation: Distributed in human breast milk Supplement calcium and vitamin D during pregnancy and lactation according to the recommended daily allowance

Interactions

It has possible interaction with digoxin, antacids containing Calcium, Aluminum or Magnesium, other Calcium supplements, Calcitriol, Tetracycline, Doxycycline, Aminocycline or Oxytetracycline etc. May affect the absorption of tetracycline when used together. Concurrent use with systemic corticosteroids may reduce calcium absorption. Thiazide diuretics may decrease urinary excretion of calcium. Concurrent use with ion-exchange resins may reduce GI absorption of vitamin D. Hypercalcaemia may increase the toxicity of cardiac glycosides during treatment with calcium and vitamin D. Bisphosphonate or sodium fluoride should be given at least 3 hr before calcium-containing preparations.

Adverse Effects

Side effects of Calcium (Coral Source) + Vitamin D3 : Calcium Anorexia,Constipation,Flatulence,Nausea,Vomiting,Hypercalcemia,Hypophosphatemia,Xerostomia,Acid rebound,Milk-alkali syndrome Vitamin D Hypercalcemia,Muscle/bone pain,Metallic taste,Headache,Nausea,Vomiting,Dry mouth,Constipation,Arrhythmias

Mechanism of Action

Calcium /vitamin D3 prevents or treats negative Ca balance. It also helps facilitate nerve and muscle performance as well as normal cardiac function. Bone mineral component; cofoactor in enzymatic reactions, essential for neurotransmission, muscle contraction, and many signal transduction pathways. Vitamin D3 is a fat-soluble sterol. It is necessary for the regulation and regulation of calcium and phosphate homoeostasis and bone mineralisation. Vitamin D is also essential for healthy bones as it aids in Calcium absorption from the GI tract. In addition to this it stimulates bone formation. Clinical studies also show that Calcium and Vitamin D has synergistic effects on bone growth as well as in Osteoporosis and fracture prevention.

Note

MarinCal-DX 600mg + 400IU Tablet manufactured by Incepta Pharmaceuticals Ltd.. Its generic name is Calcium (Coral Source) + Vitamin D3. MarinCal-DX is availble in Bangladesh. Farmaco BD drug index information on MarinCal-DX Tablet is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.

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