Lyby Lotion

Abametapir topical

0.74 %

Nuvista Pharma Ltd

Pack size	1's Pack
Dispensing mode
Source
Agent
Retail Price	600.00 AED

Indications

Lyby Lotion is used for: Head Lice

Adult Dose

Topical Lotion Head Lice Indicated for topical treatment of head lice infestation Apply to dry hair in an amount sufficient (up to the full content of one bottle) to thoroughly coat the hair and scalp

Child Dose

Topical Lotion Head Lice Indicated for topical treatment of head lice infestation in children and adolescents aged ?6 months <6 months: Safety and efficacy not established >6 months Apply to dry hair in an amount sufficient (up to the full content of one bottle) to thoroughly coat the hair and scalp

Renal Dose

Administration

Topical Administration Topical use only Not for oral, ophthalmic, or intravaginal use Treatment involves a single application Shake well before use Apply to dry hair in an amount (up to the full content of one bottle) sufficient to thoroughly coat the hair and scalp Massage into the scalp and throughout the hair Avoid contact with eyes Leave on the hair and scalp for 10 min and then rinse off with warm water Wash hands after application; shampoo hair any time after the treatment

Contra Indications

Precautions

Lotion contains benzyl alcohol; systemic exposure to benzyl alcohol has been associated with serious and fatal adverse reactions including gasping syndrome in neonates and low-birth-weight infants Safety and effectiveness have not been established in pediatric patients aged <6 months Use is not recommended in pediatric patients aged <6 months because of the potential for increased systemic absorption In order to prevent accidental ingestion in pediatric patients, only administer under direct supervision of an adult

Pregnancy-Lactation

Pregnancy No data are available on use in pregnant females to evaluate for drug-associated risk of major birth defects, miscarriage, or adverse maternal or fetal outcomes Animal data In embryofetal development studies conducted with oral administration of abametapir during organogenesis, no evidence of fetal harm or malformations, independent of maternal toxicity, were observed in pregnant rats and rabbits at doses that produced exposures up to 50 times and equivalent to the maximum recommended human dose in rats and rabbits, respectively Highest dose evaluated in rabbits was limited due to maternal toxicity associated with the vehicle used in the study Lactation No data are available regarding presence in human milk, effects on breastfed infants, or on milk production

Interactions

In vitro studies suggest potential for abametapir to inhibit CYP3A4, CYP2B6, and CYP1A2 enzymes following a single application Coadministration with substrates of these enzymes may lead to increased systemic concentrations of the interacting drugs Avoid administration of drugs that are substrates of CYP3A4, CYP2B6, or CYP1A2 within 2 weeks after abametapir application If this is not feasible, avoid abametapir use Contraindicated (0) Serious - Use Alternative (1) diazepam buccal

Adverse Effects

Side effects of Abametapir topical : 1-10% Erythema (4%) Rash (3.2%) Scalp erythema/edema (3.2%) Skin burning sensation (2.6%) Vomiting (1.7%) Contact dermatitis (1.7%) Scalp pruritus (1.4%) Eye irritation (1.2-1.7%) Hair color changes (1%)

Mechanism of Action

Metalloproteinase inhibitor Metalloproteinases have a role in physiological processes critical to egg development and survival of lice

Note

Lyby 0.74 % Lotion manufactured by Nuvista Pharma Ltd. Its generic name is Abametapir topical. Lyby is availble in Bangladesh. Farmaco BD drug index information on Lyby Lotion is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.