Leukeran Tablet

Chlorambucil

2mg

Excella, Germany

Pack size	25's pack
Dispensing mode
Source
Agent
Retail Price	45.48 AED

Indications

Leukeran Tablet is used for: Chronic lymphatic (lymphocytic) leukemia, malignant lymphomas including lymphosarcoma, giant follicular lymphoma, hodgkin’s disease

Adult Dose

Oral Tablet The usual oral dosage is 0.1 to 0.2 mg/kg body weight daily for 3 to 6 weeks as required. This usually amounts to 4 to 10 mg per day for the average patient. The entire daily dose may be given at one time. These dosages are for initiation of therapy or for short courses of treatment. Chronic Lymphatic (Lymphocytic) Leukemia 0.1 mg/kg/day for 3-6 weeks or 0.4 mg/kg (increased by 0.1 mg/kg/dose until response/toxicity observed) biweekly or 0.4 mg/kg (increased by 0.1 mg/kg/dose until response observed) monthly or 0.03-0.1 mg/kg/day continuously Reduce initial dose if administered within 4 weeks after a full course of radiation/myelosuppressive therapy or patients with bone marrow disease Not to exceed 0.1 mg/kg/day if bone marrow infiltrated with lymphocytes Hodgkin's Lymphoma 0.2 mg/kg/day for 3-6 weeks or 0.4 mg/kg (increased by 0.1 mg/kg/dose until response/toxicity observed) biweekly or 0.4 mg/kg (increased by 0.1 mg/kg/dose until response or toxicity observed) monthly or 0.03-0.1 mg/kg/day continuously Reduce initial dose if administered within 4 weeks after a full course of radiation/myelosuppressive therapy or patients with bone marrow disease Not to exceed 0.1 mg/kg/day if bone marrow infiltrated with lymphocytes

Child Dose

Renal Dose

Renal Impairment <1% (including metabolites) excreted in urine; no dose adjustment required

Administration

Should be taken on an empty stomach. Take on an empty stomach. Ensure adequate hydration. Swallow whole, do not chew/crush.

Contra Indications

Hypersensitivity or resistance; demonstrated resistance to chlorambucil previously

Precautions

Severe bone marrow suppression can occur with chlorambucil Chlorambucil is a carcinogen. Chronic therapy may produce myelocytic leukemia and secondary malignancies Chlorambucil may cause infertility. It is teratogenic and mutagenic History of seizures; head trauma; those receiving other potentially epileptogenic drugs Potentially mutagenic, carcinogenic & teratogenic; avoid pregnancy Can cause infertility Severely myelosuppressive May need lower dosages in liver failure Beware of cross-hypersensitivity w/ other alkylating agents Reduce dose in preexisting myelosuppressive situations or if WBC/Plt counts fall below normal If used within 4 week of radiation/cytotoxic chemotherapy Avoid pregnancy

Pregnancy-Lactation

Pregnancy Category: D Lactation: not known if excreted in breast milk; do not nurse

Interactions

Impairs immune response to vaccines, possible infection after admin of live vaccines. Contraindicated (1) gepirone Serious (13) adenovirus types 4 and 7 live, oral axicabtagene ciloleucel brexucabtagene autoleucel ciltacabtagene autoleucel etrasimod idecabtagene vicleucel influenza virus vaccine quadrivalent, adjuvanted influenza virus vaccine trivalent, adjuvanted lisocabtagene maraleucel palifermin ropeginterferon alfa 2b tisagenlecleucel tofacitinib

Adverse Effects

Side effects of Chlorambucil : >10% Neutropenia (25-33%),Anemia,Leukopenia,Thrombocytopenia Frequency Not Defined Seizures,Hallucinations,Peripheral neuropathy,Nausea,Vomiting,Pulmonary fibrosis,GI effects,Leukemia,Myelosuppression,Hyperuricemia,Infertility,Hepatotoxicity & jaundice,Type I hypersensitivity,Rash,Stevens-Johnson syndrome (rare),Toxic epidermal necrosis (rare),Urticaria,Erythema multiforme (rare),Secondary malignancies Potentially Fatal: Severe bone marrow suppression, carcinogenic and human infertility.

Mechanism of Action

Chlorambucil interferes with DNA replication and RNA transcription by alkylation and cross-linking cellular DNA strands, thus leading to disruption of the nucleic acid function.

Note

Leukeran 2mg Tablet manufactured by Excella, Germany. Its generic name is Chlorambucil. Leukeran is availble in Bangladesh. Farmaco BD drug index information on Leukeran Tablet is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.