Intracef DS Powder for Suspension
Cephradine
250mg/5ml
Beximco Pharmaceuticals Ltd.
| Pack size | 100ml bot |
|---|---|
| Dispensing mode | |
| Source | |
| Agent | |
| Retail Price | 120.00 AED |
Available as:
Indications
Intracef DS Powder for Suspension is used for:
Pharyngitis, sinusitis, otitis media, tonsillitis, laryngotracheo-bronchitis, Acute and chronic bronchitis, lobar and bronchopneumonia, Cystitis, urethritis, pyelonephritis, Abscess, cellulitis, furunculosis, impetigo, Bacillary dysentery, enteritis, peritonitis, Bone and joint infection, Surgical prophylaxis, Respiratory tract infections, Urinary tract infections, Skin and soft tissue infections, Gastrointestinal tract infections
Adult Dose
Adult:
Oral
250–500 mg 4 times a day,
alternatively 0.5–1 g twice daily;
increased if necessary up to 1 g 4 times a day,
increased dose may be used in severe infections
Susceptible infections: 1-2 g/day in 2-4 divided doses. Max: 4 g/day.
Surgical prophylaxis: 1-2 g pre-op. Subsequent doses may be given as needed.
Skin and skin structures and respiratory tract infection: Usual dose is 250 mg every 6 hours or 500 mg every 12 hours.
Lobar pneumonia: 500 mg every 6 hours or 1 gm every 12 hours.
Urinary tract infection: Usual dose is 500 mg every 12 hours.
Gastro-intestinal tract infection: 500 mg three to four times daily.
Injection:
IV/IM
Severe infections: 2-4 g/day in 4 divided doses. Max: 8 g/day.
Surgical prophylaxis: 1-2 gm immediately prior to surgery, by intramuscular or intravenous injection over 3-5 minutes. Subsequent parenteral or oral doses can be administered as appropriate.
Child Dose
Children
Oral
Child 7–11 years: 25–50 mg/kg daily in 2–4 divided doses
Child 12–17 years: 250–500 mg 4 times a day, alternatively 0.5–1 g twice daily; increased if necessary up to 1 g 4 times a day, increased dose may be used in severe infections
Injection
50 to 100 mg/kg/day in 4 equally divided doses.
The usual total dose may be increased up to 200-300 mg/kg/day.
Perioperative prophylaxis: Recommended dose is 1-2 gm by intramuscular or intravenous route;
subsequent parenteral or oral doses are given as appropriate.
Renal Dose
Renal impairment: For patients undergoing chronic intermittent haemodialysis: 250 mg may be given at the start of the session, repeated after 6-12 hr, then again 36-48 hr after the initial dose, and again at the start of the next haemodialysis if >30 hr have elapsed since the previous dose.
CrCl (ml/min)
>20 500 mg every 6 hr.
5-20 250 mg every 6 hr.
<5 250 mg every 12 hr.
Administration
May be taken with or without food. May be taken w/ meals to reduce GI discomfort.
Parenteral doses by deep IM or slow IV inj over 3-5 min or by IV infusion.
Reconstitution: IM: Add 2 mL or 4 mL of sterile water for inj or NaCl 0.9% inj to 500 mg or 1 g vial, respectively.
IV: Add 5 mL of sterile water for inj, dextrose 5% inj, NaCl 0.9% inj or other suitable soln to 500 mg vial. Shake well the entire soln.
Contra Indications
Hypersensitivity to cefradine or other cephalosporins; porphyria.
Precautions
Renal impairment; history of penicillin sensitivity; pregnancy; lactation.
Pregnancy-Lactation
No teratogenicity has been demonstrated in animals, but safety in pregnancy has not been established. Cefradine is excreted in the breast milk and should be used with caution in lactating mothers.
Interactions
Increased risk of nephrotoxicity w/ loop diuretics.
Decreased renal clearance w/ probenecid.
Potentially nephrotoxic (particularly Cefaloridine) and may enhance the nephrotoxicity of aminoglycoside antibiotics such as Gentamycin and Tobramycin.
Adverse Effects
Side effects of Cephradine :
Diarrhoea, nausea, vomiting, abdominal discomfort, abdominal pain, candidial overgrowth, vaginitis, leukopenia, neutropenia, eosinophilia, rash, pruritus, angioedema, anaphylaxis joint pain; increased BUN and creatine; dizziness.
Potentially Fatal: Pseudomembranous colitis.
Mechanism of Action
Cefradine is a 1st generation cephalosporin which inhibits the final transpeptidation step of the peptidoglycan synthesis in bacterial cell wall by binding to one or more of the penicillin-binding proteins (PBPs), thus arresting cell wall synthesis leading to bacterial cell death.
Note
Intracef DS 250mg/5ml Powder for Suspension manufactured by Beximco Pharmaceuticals Ltd.. Its generic name is Cephradine. Intracef DS is availble in Bangladesh.
Farmaco BD drug index information on Intracef DS Powder for Suspension is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.
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