Inclaud Tablet
Cilostazol
100mg
ACI Limited
| Pack size | 20's pack |
|---|---|
| Dispensing mode | |
| Source | |
| Agent | |
| Retail Price | 10.00 AED |
Indications
Inclaud Tablet is used for:
Intermittent claudication, Peripheral vascular disease
Adult Dose
Oral
Intermittent Claudication, Peripheral vascular disease
Adult: 100 mg bid.
May reduce dose in patients taking enzyme inhibitors concurrently.
Child Dose
Renal Dose
Renal Impairment
CrCl< 25 mL/min: Use caution
Administration
Should be taken on an empty stomach. Take at least ½ hr before or 2 hr after meals.
Contra Indications
Heart failure; known predisposition to bleeding; history of ventricular arrhythmias; QT interval prolongation; severe renal impairment; moderate to severe hepatic impairment.
Precautions
Cilostazol is contraindicated in patients with heart failure of any severity. Cilostazol and several of its metabolites are inhibitors of phosphodiesterase III. Several drugs with the pharmacologic effect have caused decreased survival compared to placebo patients with class III-IV heart failure.
Risks of tachycardia, palpitation, tachyarrhythmia or hypotension.
Risks of exacerbations of angina pectoris or myocardial infarction in patients with a history of ischemic heart disease
Left ventricular outflow tract obstruction has been reported in patients with sigmoid-shaped interventricular septum
Risks of thrombocytopenia or leukopenia progressing to agranulocytosis: monitor platelets and white blood cell counts
Avoid use in patients with hemostatic disorders or active pathologic bleeding
Pregnancy-Lactation
Pregnancy category: C
Lactation: Excretion in milk unknown; not recommended
Interactions
Co-admin with drugs that affect CYP3A4 (erythromycin, other macrolides, diltiazem) or CYP2C19 (omeprazole) may influence the pharmacokinetics of cilostazol.
Contraindicated (1)
abrocitinib
Serious (42)
antithrombin alfa
antithrombin III
apalutamide
apixaban
argatroban
aspirin rectal
bivalirudin
caplacizumab
carbamazepine
ceritinib
cimetidine
clarithromycin
dalteparin
enoxaparin
enzalutamide
erythromycin base
erythromycin ethylsuccinate
erythromycin lactobionate
erythromycin stearate
esomeprazole
fexinidazole
fluconazole
fluvoxamine
fondaparinux
gemfibrozil
heparin
idelalisib
isoniazid
ivosidenib
ketoconazole
levoketoconazole
lonafarnib
lopinavir
mifepristone
modafinil
nefazodone
omeprazole
protamine
rifabutin
rifampin
St John's Wort
tucatinib
Adverse Effects
Side effects of Cilostazol :
>10%
Headache (27-34%),Diarrhea (12-19%),Abnormal stools (12-15%),Infection (10-14%),Rhinitis (7-12%),Pharyngitis (7-10%)
1-10%
Dizziness (9-10%),Palpitations (5-10%),Peripheral edema (7-9%),Back pain (6-7%),Dyspepsia (6%),Abdominal pain (4-5%),Tachycardia (4%),Increased cough (3-4%),Myalgia (2-3%),Atrial fibrillation (<2%),CHF (<2%),MI (<2%),Hematemesis (<2%),Ecchymosis (<2%),Blood in eye (<2%),Epistaxis (<2%),Hemoptysis (<2%),Nausea
Frequency Not Defined
Decreased platelet aggregation,Agranulocytosis,Aplastic anemia,Leukopenia,Thrombocytopenia,Stevens-Johnson syndrome
Mechanism of Action
Cilostazol is a reversible, selective inhibitor of phosphodiesterase-III (PDE-III), thereby suppressing cyclic adenosine monophosphate (cAMP) degradation. Increase in cAMP in platelets and blood vessels leads to inhibition of platelet aggregation and vasodilation. Cilostazol also inhibits adenosine uptake into cells, which augments the cAMP-elevating effect of PDE-III inhibition.
Note
Inclaud 100mg Tablet manufactured by ACI Limited. Its generic name is Cilostazol. Inclaud is availble in Bangladesh.
Farmaco BD drug index information on Inclaud Tablet is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.