Gefapix Tablet
Gefapixant
45 mg
Square Pharmaceuticals PLC.
| Pack size | 20's pack |
|---|---|
| Dispensing mode | |
| Source | |
| Agent | |
| Retail Price | 35.00 AED |
Indications
Gefapix Tablet is used for:
Chronic cough
Adult Dose
Oral
Treatment of refractory chronic cough or unexplained chronic cough in adults
The recommended dose is One 45 mg tablet twice daily.
Child Dose
Renal Dose
Administration
May be taken with or without food.
Contra Indications
Used with caution in patients with known hypersensitivity to medicinal products containing active substances from the sulfonamide class of drugs.
Precautions
Gefapixant must not be used in those who are hypersensitive to the active substance or any of the excipients or in the case of hypersensitivity to sulfonamides.
Pregnancy-Lactation
Interactions
Adverse Effects
Side effects of Gefapixant :
The most frequent adverse effects are dry mouth and impairment of the sense of taste (change, decrease or complete loss).
Mechanism of Action
P2X3 receptor antagonist; purinergic receptor P2X3 is an ATP-gated ion channel found on sensory nerve fibers, predominantly C fibers, in the airway lining.
Chemical stimuli, including adenosine triphosphate (ATP), can be released from airway lining cells due to processes including airway inflammation, irritation, and mechanical stress/injury; binding of extracellular ATP to P2X3 receptors on C fibers in the airway can be sensed as a signal of potential damage, creating an action potential, which may initiate coughing.
Blockade of extracellular ATP binding to P2X3 receptors is thought to reduce sensory C fiber activation and subsequently, coughing.
Note
Gefapix 45 mg Tablet manufactured by Square Pharmaceuticals PLC.. Its generic name is Gefapixant. Gefapix is availble in Bangladesh.
Farmaco BD drug index information on Gefapix Tablet is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.