Encatrol Capsule
Calcitriol
0.25 mcg
Globe Pharmaceuticals Ltd.
| Pack size | 30's Pack |
|---|---|
| Dispensing mode | |
| Source | |
| Agent | |
| Retail Price | 10.00 AED |
Indications
Encatrol Capsule is used for:
Osteoporosis, Hypoparathyroidism, Hypocalcaemia, Osteomalacia rickets, Renal osteodystrophy, Chronic kidney dialysis.
Adult Dose
Adult: Capsule: The optimal daily dose of Calcitriol must be carefully determined for each patient on the basis of the serum calcium level.
Calcitriol can be administered orally either 0.25 mcg or 0.50 mcg.
Postmenopausal osteoporosis
The recommended dosage is 0.25 mcg twice daily or 0.50 mcg once daily. Serum creatinine levels should be determined at 4 weeks, 3 and 6 months and 6 monthly intervals thereafter.
Renal osteodystrophy (Dialysis patients)
The recommended initial dose of Calcitriol is 0.25 mcg/day. Patients with normal or only slightly reduced serum calcium levels may respond to Calcitriol doses of 0.25 mcg every other day. Most patients undergoing hemodialysis respond to doses between 0.5 and 1 mcg/day.
Hypoparathyroidism & Rickets
The recommended initial dosage of Calcitriol is 0.25 mcg/day given in the morning.
If a satisfactory response is not observed, the dose may be increased at 2 to 4-week intervals.
Predialysis patients:
The recommended initial dosage of Calcitriol is 0.25 mcg/day in adults. This dosage may be increased if necessary to 0.5 mcg/day.
Injection
Chronic Renal Dialysis Associated Hypocalcemia
The recommended intravenous initial dose of Calcitriol injection, depending on the severity of the hypocalcemia and/or secondary hyperparathyroidism, is 1 mcg (0.02 mcg/kg) to 2 mcg administered three times weekly, approximately every other day.
Doses as small as 0.5 mcg and as large as 4 mcg three times weekly have been used as an initial dose.
If a satisfactory response is not observed, the dose may be increased by 0.5 to 1 mcg at two to four-week intervals.
Child Dose
Chronic Renal Dialysis Associated Hypocalcemia
0.25-2 mcg/day PO once daily
Hypoparathyroidism/Pseudohypoparathyroidism
<1 year: 0.04-0.08 mcg/kg PO once daily
1-5 years: 0.25-0.75 mcg PO once daily
>6 years: 0.5-2 mcg PO once daily
Familial Hypophosphatemia
Initial: 0.015-0.02 mcg/kg PO once daily
Maintenance: 0.03-0.06 mcg/kg PO once daily
No more than 2 mcg PO once daily
Secondary Hyperparathyroidism in Moderate to Severe Kidney Disease
<3 years: 0.01-0.015 mcg/kg/day
>3 years: 0.25 mcg/day PO; may increase to 0.5 mcg/day
Hypocalcemia in Premature Infants
1 mcg once daily PO for 5 days
Renal Dose
Administration
May be taken with or without food. May be taken w/ meals to reduce GI discomfort.
Contra Indications
Hypercalcaemia; evidence of vitamin D toxicity. Pregnancy (dose exceeding RDA). Lactation.
Precautions
Idiopathic hypercalcemia. Pediatric doses must be individualized and monitored under close medical supervision. Coronary disease, renal function impairment and arteriosclerosis, especially in the elderly. Hypoparathyroidism.
Excessive dosage of Calcitriol induces hypercalcemia and in some instances hypercalciuria; therefore, early in treatment during dosage adjustment, serum calcium should be determined twice weekly.
Patients with normal renal function who are taking Calcitriol should avoid dehydration. Adequate fluid intake should be maintained.
MONITORING PARAMETERS
Monitor plasma calcium, phosphate, and creatinine during dosage titration.
Monitor plasma-calcium concentration in patients receiving high doses.
Pregnancy-Lactation
Pregnancy category: C
Lactation: Enters breast milk; not recommended
Interactions
Hypermagnesaemia may develop in patients on chronic renal dialysis. Hypercalcaemia in patients on digitalis may precipitate cardiac arrhythmias. Intestinal absorption of calcitriol may be reduced by cholestyramine and colestipol. Phenytoin, barbiturates may decrease the T1/2 of calcitriol. May develop hypercalcaemia with thiazide diuretics.
Contraindicated (0)
Serious (20)
apalutamide
atazanavir
carbamazepine
clarithromycin
darunavir
enzalutamide
fexinidazole
idelalisib
itraconazole
ivosidenib
lonafarnib
lopinavir
mifepristone
nafcillin
nefazodone
nelfinavir
pacritinib
posaconazole
ritonavir
tucatinib
Adverse Effects
Side effects of Calcitriol :
Frequency Not Defined
Abdominal pain
Apathy
BUN and creatinine increased
Cardiac arrhythmia
Constipation
Dry mouth
Dehydration
Growth suppression
Headache
Hyperthermia
Hypercalcemia
Hypercholesteremia
Hypermagnesemia
Hyperphosphatemia
Hypertension
Libido decreased
Metallic taste
Muscle or bone pain
N/V
Nocturia
Pruritus
Psychosis
Somnolence
Weakness
Mechanism of Action
Calcitriol promotes calcium absorption in the intestines and retention at the kidneys thus increasing serum calcium levels. It also increases renal tubule phosphate resorption consequently decreasing serum phosphatase levels, PTH levels and bone resorption..
Note
Encatrol 0.25 mcg Capsule manufactured by Globe Pharmaceuticals Ltd.. Its generic name is Calcitriol. Encatrol is availble in Bangladesh.
Farmaco BD drug index information on Encatrol Capsule is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.