Edimox Tablet
Acetazolamide
250 mg
G. A. Company Ltd.
| Pack size | |
|---|---|
| Dispensing mode | |
| Source | |
| Agent | |
| Retail Price | 2.00 AED |
Indications
Edimox Tablet is used for:
Glaucoma, Epilepsy, Idiopathic intracranial hypertension, Altitude sickness
Adult Dose
Adult: PO
Congestive Heart Failure
CHF-associated edema
250-375 mg (5 mg/kg) PO once daily in the morning
Seizure
8-30 mg/kg/day PO once daily or divided q12hr
Drug-induced Edema
250-375 mg PO once daily
Glaucoma
Closed-angle (acute congestive) glaucoma
500 mg PO, followed by 125-250 mg PO q4hr
Sustained-release: 500 mg PO q12hr
Open-angle (chronic simple) glaucoma
250 mg-1 g PO once daily or divided q6-12hr
Sustained-release: 500 mg PO q12hr
Secondary glaucoma
500 mg PO, followed by 125-250 mg PO q4hr
Sustained-release: 500 mg PO q12hr
Acute Altitude Sickness
Immediate release: 500-1000 mg/day PO divided q8-12hr
Extended-release: 500-1000 mg PO q12-24hr
Child Dose
Epilepsy
<12 years
Safety and efficacy not established
>12 years
Tablet: 8-30 mg/kg/day PO once daily or divided q6-12 hr; not to exceed 30 mg/kg/day or 1 g/day
Extended-release capsule: Not recommended
Acute Altitude Sickness
<12 years
Safety and efficacy not established
>12 years
Immediate release: 500-1000 mg/day PO divided q8-12hr
Extended-release: 500-1000 mg PO q12-24hr
Renal Dose
Renal impairment
CrCl 10-50 mL/min: Administer no more frequently than q12hr
CrCl <10 mL/min: Ineffective (avoid use)
Hemodialysis: 20-50% dialyzable
Peritoneal dialysis: Dose adjustment not necessary
Administration
Should be taken with food.
Contra Indications
Hypersensitivity to sulphonamides; sodium or potassium depletion, hepatic insufficiency; hepatic cirrhosis; hyperchloraemic acidosis; severe renal impairment; severe pulmonary obstruction; chronic noncongestive angle-closure glaucoma; adrenocortical insufficiency. Pregnancy, lactation.
Precautions
Potassium supplements may be required. Impaired hepatic or renal function; diabetes. Monitor plasma electrolytes and blood count regularly. IM route is not recommended. Caution when driving or operating machinery. Elderly.
Pregnancy-Lactation
Pregnancy category: C
Lactation: Enters breast milk; not recommended
Interactions
Concomitant use w/ high-dose aspirin may cause anorexia, tachypnoea, lethargy, metabolic acidosis, coma and death. May increase serum levels of phenytoin, resulting to increased risk of osteomalacia. May decrease serum concentrations of primidone. Additive effects w/ other carbonic anhydrase inhibitors. May increase the effects of folic acid antagonists. May decrease urinary excretion of amphetamine and quinidine. May prevent the urinary antiseptic effect of methenamine. May increase lithium excretion. Increased risk of renal calculus formation w/ Na bicarbonate. May increase ciclosporin levels.
Contraindicated (0)
Serious - Use Alternative (3)
methenamine
olopatadine intranasal
zuranolone
Adverse Effects
Side effects of Acetazolamide :
Drowsiness, paraesthesia, ataxia, dizziness, thirst, anorexia, headache; confusion, malaise, depression; GI distress, metabolic acidosis, polyuria, hyperuricaemia, renal calculi, nephrotoxicity, hepatic dysfunction.
Potentially Fatal: Rarely, skin reactions or blood dyscrasias.
Mechanism of Action
Acetazolamide specifically inhibits the enzyme carbonic anhydrase which catalyses the reversible reaction involving the hydration of CO2 and dehydration of carbonic acid. It increases the excretion of HCO3 ions and as well as Na and K leading to alkaline diuresis. Carbonic anhydrase is also inhibited in the CNS to retard abnormal and excessive discharge from neurons.
Note
Edimox 250 mg Tablet manufactured by G. A. Company Ltd.. Its generic name is Acetazolamide. Edimox is availble in Bangladesh.
Farmaco BD drug index information on Edimox Tablet is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.