Eclo Plus Ointment

Clobetasol Propionate + Salicylic Acid topical

.05%

General Pharmaceuticals Ltd.

Pack size	10g
Dispensing mode
Source
Agent
Retail Price	68.00 AED

Indications

Eclo Plus Ointment is used for: Psoriasis, Burns, Acne vulgaris, Eczema, Dyskeratosis, Ichthyosis, Warts, Hyperkeratosis, Corn, Callus, Seborrhea, Scaly skin disease, Hair loss, Sweating feet, Dermatitis

Adult Dose

Adult: Topical Acne; Hyperkeratotic and scaling skin conditions As 2-6% Salicylic Acid preparation: Apply a thin layer of this ointment to the affected skin areas 3 times/day.

Child Dose

Renal Dose

Administration

Contra Indications

Hypersensitivity

Precautions

Not for prolonged use in high concentrations and on large areas of the body. Impaired peripheral circulation or diabetes. Avoid broken skin, mouth, eyes, mucous membranes and anogenital region.

Pregnancy-Lactation

Topical administration of corticosteroids to pregnant animals can cause abnormalities of fetal development. The relevance of this finding to human beings has not been established. The safe use of Clobetasol Propionate during lactation has not been established. However, the administration of Clobetasol Propionate during pregnancy and lactation should only be considered if the expected benefit to the mother is greater than any possible risk to the fetus. Drugs of this class should not be used extensively in pregnant patients in large amounts or for prolonged periods of time. Whilst there are no known contra-indications to the use of Salicylic Acid ointment during pregnancy and lactation, the safety has not been established. Salicylic Acid ointment shold therefore be used with caution.

Interactions

Clobetasol Propionate: Increased systemic exposure w/ CYP3A4 inhibitors (eg ritonavir & itraconazole).

Adverse Effects

Side effects of Clobetasol Propionate + Salicylic Acid topical : Prolonged usage of large amount of clobetasol propionate can lead to sufficient systemic levels to produce adrenal suppression, Cushing's syndrome, diabetes and hypertension. Dermal and epidermal atrophy esp on the face, steroid purpura

Mechanism of Action

Clobetasol Propionate high potency corticosteroid. Corticosteroids decrease inflammation by stabilizing leukocyte lysosomal membranes, preventing release of destructive acid hydrolases from leukocytes; inhibiting macrophage accumulation in inflamed areas; reducing leukocyte adhesion to capillary endothelium; reducing capillary wall permeability and edema formation; decreasing complement components; antagonizing histamine activity and release of kinin from substrates; and reducing fibroblast proliferation, collagen deposition, and subsequent scar tissue formation. Salicylic acid has a potent keratolytic action and a slight antiseptic action when applied topically. It softens and destroys the stratum corneum by increasing endogenous hydration which causes the horny layer of the skin to swell, soften, and then desquamate. At high concentrations, salicylic acid has a caustic effect. It also possesses weak antifungal and antibacterial activity.

Note

Eclo Plus .05% Ointment manufactured by General Pharmaceuticals Ltd.. Its generic name is Clobetasol Propionate + Salicylic Acid topical. Eclo Plus is availble in Bangladesh. Farmaco BD drug index information on Eclo Plus Ointment is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.

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