Dytor Tablet
Torasemide (Torsemide)
5mg
UniMed UniHealth Pharmaceuticals Ltd.
| Pack size | 28's pack |
|---|---|
| Dispensing mode | |
| Source | |
| Agent | |
| Retail Price | 11.00 AED |
Available as:
Indications
Dytor Tablet is used for:
Oedema, Hepatic Cirrhosis, Hypertension
Adult Dose
Oral
Oedema
Indicated for the treatment of oedema associated with heart failure or renal disease
10-20 mg PO once daily initially; may increase the dose by doubling until the desired diuretic effect is achieved
Doses >200 mg have not been adequately studied
Hepatic Cirrhosis
Indicated for the treatment of oedema associated with hepatic disease
5-10 mg PO once daily initially with aldosterone antagonist or potassium-sparing diuretic; may increase the dose by doubling until desired diuretic effect achieved
Max: 40 mg daily.
Hypertension
The recommended initial dose is 5 mg once daily. After 4-6 weeks, increase to 10 mg once daily, if needed.
If 10 mg is insufficient, consider adding another agent.
Hepatic impairment
No dosage adjustments provided in prescribing information
Use with caution
Contraindicated in hepatic coma
Child Dose
Renal Dose
Renal impairment
No dosage adjustments provided in prescribing information
Higher doses may be required to achieve diuretic effect
Administration
May be taken with or without food.
Contra Indications
Hypersensitivity to torsemide or to povidone. Hypersensitivity to sulfonylureas, renal failure with anuria, hepatic coma and pre-coma, hypotension, cardiac arrhythmias. Pregnancy and lactation.
Precautions
Patient with difficulty in micturition including prostatic hypertrophy, hyperuricaemia, gout, diabetes mellitus, cardiac arrhytmias (e.g. sino-atrial-block, 2nd or 3rd degree atrioventricular block). Patient with CV disease (particularly those receiving cardiac glycosides); liver cirrhosis and ascites (IV).
Patient undergoing surgery; avoid use in the immediate postoperative period after bariatric surgery.
Monitor fluid status and renal function to prevent azotemia, oliguria, and reversible increases in blood urea nitrogen (BUN) and creatinine
Can cause potentially symptomatic hypokalemia, hyponatremia, hypomagnesemia, hypocalcemia, and hypochloremic alkalosis; therapy can cause an increase in blood glucose levels and hyperglycemia; asymptomatic hyperuricemia can occur, and gout may rarely be precipitated; monitor serum electrolytes and blood glucose periodically
Not recommended for the initial treatment of hypertension. Not for use in the treatment of hypertension in patients with Addison's disease. Renal and hepatic impairment. Pregnancy and lactation.
Pregnancy-Lactation
Pregnancy
No data are available on use in pregnant females and risk of major birth defects or miscarriage
Animal data
In pregnant rats and rabbits administered 50x and 6.8x the human dose, decreases in body weight, decreased fetal resorption, and delayed ossification was observed
Lactation
There are no data regarding presence of torsemide in human milk or effects of on breastfed children
Diuretics can suppress lactation
Interactions
Increased risk of severe hypokalaemia with amphotercin B, corticosteroids, carbenoxolone, hypokalaemia-causing medications. Increased risk of lithium toxicity. Increased potential for ototoxicity and nephrotoxicity with nephrotoxic or ototoxic medications e.g. aminoglycosides. High dose salicylates may increase the risk of salicylate toxicity. Increased risk of toxicity with digoxin. Reduced diuretic effect with NSAIDs. Increased risk of hypotension with antihypertensives.
Adverse Effects
Side effects of Torasemide (Torsemide) :
1-10%
Excessive urination (7%)
Headache (7%)
Electrolyte imbalance (2-4%)
Dizziness (3%)
Rhinitis (3%)
Constipation (2%)
Cough (2%)
Diarrhea (2%)
Dyspepsia (2%)
Nausea (2%)
Insomnia (1%)
Nervousness (1%)
Mechanism of Action
Torasemide, a sulfonylurea loop diuretic, acts from within the lumen of the thick ascending portion of the loop of Henle, where it inhibits the Na+/K+/2CI--carrier system.
Note
Dytor 5mg Tablet manufactured by UniMed UniHealth Pharmaceuticals Ltd.. Its generic name is Torasemide (Torsemide). Dytor is availble in Bangladesh.
Farmaco BD drug index information on Dytor Tablet is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.