Disprin CV Tablet
Aspirin
100mg
Reckitt & Benckiser Bangladesh Ltd.
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| Retail Price | 0.80 AED |
Available as:
Indications
Disprin CV Tablet is used for:
Fever, Headache, Pain/inflammation, Acute coronary syndrome, TIA, MI, Stroke
Adult Dose
PO
Prophylaxis of myocardial infarction
Adult: 75-300 mg once daily. Lower doses should be used in patients receiving ACE inhibitors.
Stent implantation
Adult: 300 mg 2 hr before procedure followed by 150-300 mg/day thereafter.
Mild to moderate pain and fever
Adult: 150-300 mg repeated every 4-6 hr according to response. Max: 4 g/day.
Pain and inflammation associated with musculoskeletal and joint disorders
Adult: Initial: 2.4-3.6 g/day in divided doses. Usual maintenance: 3.6-5.4 g/day. Monitor serum concentrations.
Child Dose
PO
Juvenile rheumatoid arthritis
Child: <25 kg: 60-100 mg/kg/day PO divided q6-8hr (maintain serum salicylate at 150-300 mcg/mL)
>25 kg: 2.4-3.6 g/day
Pain & Fever
<12 years
10-15 mg/kg PO q4hr, up to 60-80 mg/kg/day
Renal Dose
Renal impairment
CrCl >10 mL/min: Dose adjustment not necessary
CrCl <10 mL/min: Not recommended
Administration
Should be taken with food.
Contra Indications
Hypersensitivity (attacks of asthma, angioedema, urticaria or rhinitis), active peptic ulceration; pregnancy (3rd trimester), children <12 yr, patients with hemophilia or hemorrhagic disorders, gout, severe renal or hepatic impairment, lactation.
Absolute
Bleeding GI ulcers, hemolytic anemia from pyruvate kinase (PK) and glucose-6-phosphate dehydrogenase (G6PD) deficiency, hemophilia, hemorrhagic diathesis, hemorrhoids, lactating mother, nasal polyps associated with asthma, sarcoidosis, thrombocytopenia, ulcerative colitis
Relative
Appendicitis, asthma (bronchial), chronic diarrhea, bowel outlet obstruction (for enteric-coated formulations), dehydration, erosive gastritis, hypoparathyroidism
Precautions
Anemia, GI malabsorption, history of peptic ulcers, gout, hepatic disease, hypochlorhydria, hypoprothrombinemia, renal impairment, thyrotoxicosis, vitamin K deficiency, renal calculi, ethanol use (may increase bleeding)
Discontinue therapy if tinnitus develops
Should be taken with food or 8-12 oz of water to avoid GI effects
Not indicated for children with viral illness; use of salicylates in pediatric patients with varicella or influenzalike illness is associated with increased incidence of Reye syndrome
Heart Failure (HF) risk
NSAIDS have the potential to trigger HF by prostaglandin inhibition that leads to sodium and water retention, increased systemic vascular resistance, and blunted response to diuretics
High-dose aspirin (greater than 325mg) should be avoided or withdrawn whenever possible
Pregnancy-Lactation
Pregancy
Avoid chronic or intermittent high doses during pregnancy; may affect maternal and newborn hemostasis mechanisms, leading to an increased risk of hemorrhage
High doses may also increase perinatal mortality by intrauterine growth restriction and teratogenic effects
Near term, aspirin may prolong gestation and labor
Premature closure of the ductus arteriosus may occur if used near term with use of full-dose aspirin
Lactation
Drug enters breast milk; a decision should be made regarding whether to discontinue nursing or to discontinue drug, taking into account importance of drug to mother
Interactions
Alcohol: do not take Aspirin 2 hours before or 1 hour after consuming alchohol
Dual inhibition of the renin-angiotensin system: Increased risk of renal impairment, hypotension and hyperkalemia
Anticoagulant and antiplatelets: increased risk of bleeding
Anticonvulsants: decreased phenytoin concentration and increased serum valproic acid levels
Methotrexate: increased risk of bone marrow toxicity
NSAIDs: Increased risk of bleeding. Nonselective NSAIDs may interfere with Aspirins antiplatelet effect
Potentially Fatal: May potentiate effects of anticoagulants, methotrexate and oral hypoglycemic.
Contraindicated (3)
abrocitinib
dichlorphenamide
mifepristone
Serious - Use Alternative (25)
benazepril
caplacizumab
captopril
enalapril
fosinopril
ibuprofen
ibuprofen IV
ketorolac
ketorolac intranasal
lesinurad (DSC)
lisinopril
macimorelin
measles, mumps, rubella and varicella vaccine, live
methotrexate
mifepristone
mitotane
moexipril
pemetrexed
perindopril
probenecid
quinapril
ramipril
ticlopidine
trandolapril
varicella virus vaccine live
Adverse Effects
Side effects of Aspirin :
Frequency Not Defined
Angioedema
Bronchospasm
CNS alteration
Dermatologic problems
GI pain, ulceration, bleeding
Hepatotoxicity
Hearing loss
Nausea
Platelet aggregation inhibition
Premature hemolysis
Pulmonary edema (salicylate-induced, noncardiogenic)
Rash
Renal damage
Tinnitus
Urticaria
Vomiting
Potentially Fatal: Gastric erosion, ulceration and bleeding; severe, occasionally fatal exacerbation of airway obstruction in asthma; Reye's syndrome (children <12 yr). Hepatotoxicity; CNS depression which may lead to coma; CV collapse and resp failure; paroxysmal bronchospasm and dyspnoea.
Mechanism of Action
Aspirin is an analgesic, anti-inflammatory and antipyretic. It inhibits cyclooxygenase, which is responsible for the synthesis of prostaglandin and thromboxane. It also inhibits platelet aggregation.
Note
Disprin CV 100mg Tablet manufactured by Reckitt & Benckiser Bangladesh Ltd.. Its generic name is Aspirin. Disprin CV is availble in Bangladesh.
Farmaco BD drug index information on Disprin CV Tablet is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.