Diclox Capsule
Dicloxacillin
500mg
Novartis (Bangladesh) Ltd.
| Pack size | 40's pack |
|---|---|
| Dispensing mode | |
| Source | |
| Agent | |
| Retail Price | 445.20 AED |
Available as:
Indications
Diclox Capsule is used for:
Pneumonia, Endocarditis, Impetigo, Cellulitis, Septic Arthritis, Surgical Prophylaxis, Otitis externa, Staphylococcal skin infections, Folliculitis, Boils, Carbuncles, Mastitis, Osteomyelitis, Throat infections, Streptococcus Septicaemia
Adult Dose
Oral
Staphylococcus aureus infections
125-500 mg PO 6 hourly
Child Dose
Child:
PO
12–25 mg/kg/day 6 hourly
For bone and joint infections, up to 100 mg/kg/day
Infections
Indicated for Staphylococcus aureus infections
<40 kg: 12.5-25 mg/kg/day PO divided q6hr
Severe infection: 50-100 mg/kg/day PO divided q6hr
>40 kg: 125-500 mg PO q6hr
Renal Dose
Renal Impairment
Not studied; total dosage reduction should be considered
Administration
Should be taken on an empty stomach. Take on an empty stomach at least 1 hr before or 2 hr after meals.
Contra Indications
Hypersensitivity to penicillins, cephalosporins, imipenem
Initial treatment of severe infections
Concomitant live bacterial vaccines
Precautions
Very high doses in poor renal function (risk of neurotoxicity) or heart failure.
Skin sensitization may occur on direct contact.
Monitor serum K concentration, renal and hematological status.
Spirochete infections particularly syphilis;
Suprainfection with penicillin-resistant organisms with prolonged use;
Avoid the intrathecal route;
Elderly;
Porphyria.
Monitor PT if patient is taking warfarin concurrently
Elimination of drug in neonates is slow; use caution
Pregnancy-Lactation
Pregnancy Category: B
Lactation: excreted in breast milk, use caution
Interactions
Probenecid prolongs serum levels of dicloxacillin.
Bacteriostatic drugs (e.g. chloramphenicol, tetracyclines) may antagonise the bactericidal effect of dicloxacillin.
May reduce anticoagulant response to dicumarol and warfarin.
May increase risk of methotrexate toxicity.
May diminish the effect of live vaccines (e.g. typhoid vaccine).
Contraindicated (0)
Serious (11)
BCG vaccine live
cholera vaccine
demeclocycline
doxycycline
microbiota oral
minocycline
omadacycline
pacritinib
sarecycline
tetracycline
typhoid vaccine live
Adverse Effects
Side effects of Dicloxacillin :
1-10%
Abdominal pain,Diarrhea,Nausea
<1%
Anemia,Elevated LFTs,Fever,Hypersensitivity,Nephritis,Pseudomembranous colitis,Seizures with extremely high doses &/or renal failure,Rash (maculopapular to exfoliative),Vomiting,Vaginitis
Potentially Fatal: Anaphylaxis.
Mechanism of Action
Dicloxacillin has antimicrobial action similar to benzylpenicillin and includes penicillinase-producing and non-penicillinase-producing staphylococci. It is active against streptococci eg, S. pneumoniae and S. pyogenes is < that of benzylpenicillin, but sufficient to be useful when these organisms are present with penicillin-resistant staphylococci. It is ineffective against E. faecalis.
Note
Diclox 500mg Capsule manufactured by Novartis (Bangladesh) Ltd.. Its generic name is Dicloxacillin. Diclox is availble in Bangladesh.
Farmaco BD drug index information on Diclox Capsule is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.