Dextran 70 IV IV Infusion
Dextran 70 + Sodium Chloride
Institute of Public Health
| Pack size | 500ml bag |
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Indications
Dextran 70 IV IV Infusion is used for:
Peritonitis, Thromboembolic disorders, Hypovolaemic shock, Pulmonary embolism, Venous thrombosis, Open heart surgery, Paralytic ileus, Pancreatitis
Adult Dose
Intravenous
Hypovolaemic shock
Adult: As dextran 70: Initially, 500-1000 mL of a 6% solution in sodium chloride 0.9% infused at a rate of 20-40 mL/min.
Maintenance: 10 ml/kg/day for3 days (Dextran 70).
Prophylaxis of pulmonary embolism or venous thrombosis in moderate- to high-risk patients undergoing surgery
Adult: As dextran 70: Initially, 500-1000 mL of a 6% solution in sodium chloride 0.9% infused over 4-6 hr during or immediately after surgery, followed by 500 mL on the next day and on subsequent alternate days for up to 2 wk after surgery in high-risk patients.
Intrauterine
As an aid in hysteroscopy
Adult: As dextran 70: 50-100 mL of a 32% solution is instilled into the uterus as a rinsing and dilatation fluid.
Child Dose
Renal Dose
Renal impairment: Extreme caution
Administration
Contra Indications
Allergy to corn products. Hypersensitivity. Severe renal disease with oliguria or anuria. Marked cardiac decompensation. Pregnancy. Thrombocytopenia, Hypofibrinogenemia
Precautions
Not a substitute for blood or blood components
Administration may cause fluid overload; use with caution in patients at risk from overexpansion of blood volume (eg, very young, elderly patients, or those with heart failure)
Large volumes of dextran (doses >1000 mL) may cause reduction in hemoglobin concentration and excessive dilution of plasma proteins due to hemodilution; transient prolongation of bleeding time or increase in bleeding tendency may occur with large volumes; use caution to prevent a decrease in hematocrit <30%.
Severe and fatal anaphylactoid reactions reported; discontinue use immediately with signs of hypersensitivity and administer appropriate therapy.
Use with caution in heart failure patients; monitor closely for fluid overload
Use with caution in patients with active hemorrhage; may increase risk of more bleeding
Renal failure reported with use; use with caution in patients with renal impairment; fluid status including urine output should be monitored closely; excessive dosing may precipitate renal failure in patients with advanced renal disease; use in severe oliguria or anuria is contraindicated
Use with caution in patients with thrombocytopenia; doses >1000 mL may interfere with platelet function and transiently prolong bleeding time; observe for bleeding
Pregnancy-Lactation
Interactions
Dextran: Enzyme inducers e.g. phenytoin or carbamazepine and enzyme inhibitors e.g. cimetidine.
Sodium Chloride: May affect serum concentrations of lithium.
Adverse Effects
Side effects of Dextran 70 + Sodium Chloride :
Frequency Not Defined
Congestive heart failure
Mild hypotension
Tightness of chest
Thrombocytopenia
Anaphylaxis
Injection site infection/phlebitis
Acute renal failure
Acidosis (if NaCl soln used)
Pulmonary edema
Wheezing
Mechanism of Action
Dextrans produce expansion of plasma volume. It also reduces blood viscosity and inhibits sludging or aggregation of red blood cells.
Note
Dextran 70 IV IV Infusion manufactured by Institute of Public Health. Its generic name is Dextran 70 + Sodium Chloride. Dextran 70 IV is availble in Bangladesh.
Farmaco BD drug index information on Dextran 70 IV IV Infusion is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.