Dextran 40 IV IV Infusion

Dextran 40 10% + Dextrose 5%
Institute of Public Health
Pack size 500ml bag
Dispensing mode
Source
Agent
Retail Price

Indications

Dextran 40 IV IV Infusion is used for: Thromboembolic disorders, Hypovolaemic shock, Pulmonary embolism, Venous thrombosis

Adult Dose

Intravenous Thromboembolic disorders Adult: As dextran 40: Initially, 500 ml of a 10% solution in glucose 5% infused over 4-6 hr, followed by 500 ml infused over 4-6 hr on the next and subsequent alternate days for not more than 10 days. Prophylaxis of postoperative thromboembolic disorders Adult: As dextran 40: 500 ml of a 10% solution in glucose 5% infused over 4-6 hr during or at the end of the surgery. Dose may be repeated the following day and treatment may be continued on alternate days for up to 10 days in high-risk patient. Hypovolaemic shock Adult: As dextran 40: Initially, 10 ml/kg given by rapid infusion as a 10% solution in glucose 5%. Doses may be given daily for up to 5 days.

Child Dose

Intravenous Thromboembolic disorders Child: As dextran 40: Up to 5 ml/kg in infants and 10 ml/kg in children. Prophylaxis of postoperative thromboembolic disorders Child: As dextran 40: Up to 10 ml/kg in children.

Renal Dose

Renal Impairment Extreme caution

Administration

IV Administration Infuse first 500 mL over 15-30 min, then slow infusion

Contra Indications

Hypersensitivity. Severe renal disease with oliguria or anuria. Marked cardiac decompensation. Pregnancy.

Precautions

Not a substitute for blood or blood components Administration may cause fluid overload; use with caution in patients at risk from overexpansion of blood volume (eg, very young, elderly patients, or those with heart failure) Large volumes of dextran (doses >1000 mL) may cause reduction in hemoglobin concentration and excessive dilution of plasma proteins due to hemodilution; transient prolongation of bleeding time or increase in bleeding tendency may occur with large volumes; use caution to prevent a decrease in hematocrit <30%. Severe and fatal anaphylactoid reactions reported; discontinue use immediately with signs of hypersensitivity and administer appropriate therapy. Use with caution in heart failure patients; monitor closely for fluid overload Use with caution in patients with active hemorrhage; may increase risk of more bleeding Renal failure reported with use; use with caution in patients with renal impairment; fluid status including urine output should be monitored closely; excessive dosing may precipitate renal failure in patients with advanced renal disease; use in severe oliguria or anuria is contraindicated Use with caution in patients with thrombocytopenia; doses >1000 mL may interfere with platelet function and transiently prolong bleeding time; observe for bleeding

Pregnancy-Lactation

Interactions

Dextran: Enzyme inducers e.g. phenytoin or carbamazepine and enzyme inhibitors e.g. cimetidine.

Adverse Effects

Side effects of Dextran 40 10% + Dextrose 5% : Frequency Not Defined Congestive heart failure Mild hypotension Tightness of chest Thrombocytopenia Anaphylaxis Injection site infection/phlebitis Acute renal failure Acidosis (if NaCl soln used) Pulmonary edema Wheezing

Mechanism of Action

Dextrans produce expansion of plasma volume. It also reduces blood viscosity and inhibits sludging or aggregation of red blood cells.

Note

Dextran 40 IV IV Infusion manufactured by Institute of Public Health. Its generic name is Dextran 40 10% + Dextrose 5%. Dextran 40 IV is availble in Bangladesh. Farmaco BD drug index information on Dextran 40 IV IV Infusion is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.

Some other brands of Dextran 40 10% + Dextrose 5% :